Evidence map›Paper›PMID 34988833›Full record

ArticleAnnals of surgical oncology2022

Long-Term Oncological and Functional Outcomes After Robot-Assisted Partial Nephrectomy for Clinically Localized Renal Cell Carcinoma.

Hugo Otaola-Arca, Alfred Krebs, Hugo Bermúdez, Raúl Lyng, Marcelo Orvieto, Alberto Bustamante, Conrado Stein, Andrés Labra, Marcela Schultz, Mario I Fernández

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In one paragraph

Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. [Robot-assisted laparoscopic inferior vena cava segmental resection for renal tumor with tumor thrombus invading the vascular wall].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025
    Article
  4. Robot-Assisted Laparoscopic Nephrectomy for Wilms' Tumour in Children.The international journal of medical robotics + computer assisted surgery : MRCAS · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hugo Otaola-ArcaDepartment of Urology, Clínica Alemana de Santiago, Santiago, Chile.
Alfred KrebsDepartment of Urology, Clínica Alemana de Santiago, Santiago, Chile.
Hugo BermúdezDepartment of Urology, Clínica Alemana de Santiago, Santiago, Chile.
Raúl LyngDepartment of Urology, Clínica Alemana de Santiago, Santiago, Chile.
Marcelo OrvietoDepartment of Urology, Clínica Alemana de Santiago, Santiago, Chile.
Alberto BustamanteDepartment of Urology, Clínica Alemana de Santiago, Santiago, Chile.
Conrado SteinDepartment of Urology, Clínica Alemana de Santiago, Santiago, Chile.
Andrés LabraFaculty of Medicine, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
Marcela SchultzFaculty of Medicine, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
Mario I FernándezDepartment of Urology, Clínica Alemana de Santiago, Santiago, Chile. mfernandeza@alemana.cl.
Clínica Alemana · CLUniversidad del Desarrollo · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate long-term oncological and renal function outcomes in patients treated with robot-assisted partial nephrectomy (RAPN) for renal cell carcinoma (RCC). PATIENTS AND

methodsPatients undergoing RAPN for clinically localized RCC between January 2014 and December 2019 at a tertiary robotic reference center were evaluated. Clinical course, pathologic characteristics, and long-term outcomes were obtained from our institutional review board-approved RCC database.

resultsA total of 234 patients were available for analysis. Median follow-up was 46 months (10.8-97.8 months), with 77 patients (32.9%) having at least 5-years of follow-up. Pathology revealed clear-cell RCC in 67.5% (n = 158). Among unfavorable factors, nuclear grades 3 or 4 were found in 67 (29.4%), lymphovascular invasion in 10 (4.3%), positive surgical margins in 22 (9.4%), necrosis in 21 (9%), and sarcomatoid pattern in 2 patients (0.9%). At 12 months, mean serum creatinine was 1.04 mg/dL and 12.9% of patients experienced upstaging in chronic kidney disease. Overall recurrence-free survival at 5-years was 97.8%. There were five local (2.1%) and two distant (0.9%) recurrences, none of them resulting in cancer-specific death. Median time to recurrence was 20 months (11-64 months). Warm ischemia time [hazard ratio (HR) = 1.14, p = 0.034] and sarcomatoid pattern (HR = 124.57, p = 0.001) were the only variables associated with local relapse.

conclusionsData from this large cohort demonstrate that patients undergoing RAPN have a low incidence of local and distant relapse, resulting in excellent long-term survival while preserving stable renal function in most patients.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsRoboticsRobotic Surgical ProceduresHumansNeoplasm Recurrence, LocalNephrectomyRetrospective StudiesTreatment Outcome

Identifiers

PMID34988833
OpenAlexW4205995346

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.