Evidence map›Paper›PMID 34988827›Full record

ReviewDrug delivery and translational research2022

Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms.

Serena Bertoni, Dritan Hasa, Beatrice Albertini, Beatrice Perissutti, Mario Grassi, Dario Voinovich, Nadia Passerini

Abstract readReview
PubMed Publisher
In one paragraph

Review in Drug delivery and translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Serena Bertoni *Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via S. Donato 19/2, 40127, Bologna, Italy.
Dritan Hasa *Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127, Trieste, Italy.
Beatrice AlbertiniDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via S. Donato 19/2, 40127, Bologna, Italy.
Beatrice PerissuttiDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127, Trieste, Italy.
Mario GrassiDepartment of Engineering and Architecture, University of Trieste, Via Alfonso Valerio, 6/1, 34127, Trieste, Italy.
Dario VoinovichDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127, Trieste, Italy.
Nadia PasseriniDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via S. Donato 19/2, 40127, Bologna, Italy. nadia.passerini@unibo.it.ORCID http://orcid.org/0000-0002-3470-2700

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last decades, Green Chemistry has been gaining widespread attention within the pharmaceutical field. It is thus very important to bring more sustainable approaches into the design and manufacture of effective oral drug delivery systems. This review focuses on spray congealing and mechanochemical activation, two technologies endorsing different principles of green chemistry, and at the same time, addressing some of the challenges related to the transformation of poorly water-soluble drugs in highly bioavailable solid dosage forms. We therefore present an overview of the basic principles, equipment, and application of these particle-engineering technologies, with specific attention to case studies carried out by the groups working in Italian Universities.

Indexed as

Drug Delivery SystemsTechnology, PharmaceuticalPharmaceutical PreparationsSolubilityPharmaceutical PreparationsBioavailability enhancementLow melting carriersMechanochemistryMicroparticlesPolymersSolid dispersionsSpray chilling

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.