Evidence map›Paper›PMID 34988704›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Nutritional status alterations after chimeric antigen receptor T cell therapy in patients with hematological malignancies: a retrospective study.

Shuyi Ding, Lingxia Cai, Aiyun Jin, Xiaoyu Zhou, Jiali Yan, Linqin Wang, Houli Zhao, Tingting Wang, Yongxian Hu

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

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9citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shuyi DingNursing Department, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Lingxia CaiNursing Department, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Aiyun JinNursing Department, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xiaoyu ZhouNursing Department, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Jiali YanNursing Department, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Linqin WangBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou, China.
Houli ZhaoBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou, China.
Tingting WangDepartment of Nutrition, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yongxian HuBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou, China. huyongxian2000@aliyun.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe influence of innovative chimeric antigen receptor T cell (CAR-T) therapy for hematological malignancies on nutritional status remains unknown. Therefore, we aim to explore the alterations of nutritional status after CAR-T cell therapy in patients with hematological malignancies.

methodsWe retrospectively collected the data of patients with acute leukemia (AL), lymphoma, and multiple myeloma (MM), who underwent CAR-T therapy at our hospital from 2018 to 2020. The serum albumin, triglyceride, and cholesterol before and 7, 14, and 21 days after CAR-T cell infusion were compared and analyzed.

resultA total of 117 patients were enrolled, consisting of 39 AL, 23 lymphoma, and 55 MM patients. The baseline albumin, triglyceride, and cholesterol were 37.43 ± 5.08 mg/L, 1.63 ± 0.74 mmol/L, and 3.62 ± 1.03 mmol/L, respectively. The lowest albumin level was found at 7 days after CAR-T cell infusion compared with baseline (P < 0.001), while the levels of triglyceride increased at 14 and 21 days (P < 0.001, P = 0.036). The levels of cholesterol at 7, 14, and 21 days after CAR-T cell infusion were lower than baseline (all P < 0.05). Spearman's correlation coefficient showed cytokine release syndrome grade was negatively correlated with the levels of albumin at 7 days and cholesterol at 21 days after CAR-T cell infusion (r =  - 0.353, P < 0.001; r =  - 0.395, P = 0.002).

conclusionThe alterations of different nutrition-related biochemical parameters varied after CAR-T cell therapy. The levels of albumin and total cholesterol after CAR-T cell infusion were negatively correlated with the grade of cytokine release syndrome. Specific screening and intervention for malnutrition in patients receiving CAR-T cell therapy need to be explored in further studies.

Indexed as

Hematologic NeoplasmsImmunotherapy, AdoptiveNutritional StatusCell- and Tissue-Based TherapyHumansReceptors, Chimeric AntigenRetrospective StudiesReceptors, Chimeric AntigenCAR-T therapyCytokine release syndromeHematological malignanciesNutritional status

Identifiers

PMID34988704

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.