Evidence map›Paper›PMID 34988680›Full record

ArticleCellular and molecular life sciences : CMLS2022

Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.

Jose Sanchez-Collado, Jose J Lopez, Isaac Jardin, Alejandro Berna-Erro, Pedro J Camello, Carlos Cantonero, Tarik Smani, Gines M Salido, Juan A Rosado

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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  7. The Molecular Heterogeneity of Store-Operated CaInternational journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jose Sanchez-Collado *Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003, Caceres, Spain.
Jose J Lopez *Department of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003, Caceres, Spain. jjlopez@unex.es.
Isaac JardinDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003, Caceres, Spain.
Alejandro Berna-ErroDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003, Caceres, Spain.
Pedro J CamelloDepartment of Physiology, (Smooth Muscle Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003, Caceres, Spain.
Carlos CantoneroDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003, Caceres, Spain.
Tarik SmaniDepartment of Medical Physiology and Biophysics, University of Seville, Seville, Spain.
Gines M SalidoDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003, Caceres, Spain.
Juan A RosadoDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003, Caceres, Spain. jarosado@unex.es.ORCID http://orcid.org/0000-0002-9749-2325
Universidad de Extremadura · ESInstituto de Biomedicina de Sevilla · ES

Funding

Agencia Estatal de Investigación PID2019-104084GB-C21Agencia Estatal de Investigación PID2019-104084GB-C22Consejería de Educación y Empleo, Junta de Extremadura DPCI0643Consejería de Educación y Empleo, Junta de Extremadura GR18061Consejería de Educación y Empleo, Junta de Extremadura IB18025Consejería de Educación y Empleo, Junta de Extremadura IB20007Consejería de Educación y Empleo, Junta de Extremadura PD16072Consejería de Educación y Empleo, Junta de Extremadura TA18011Consejería de Educación y Empleo, Junta de Extremadura TA18054
6 · The paper itself

Abstract

The identification of two variants of the canonical pore-forming subunit of the Ca

Indexed as

CalciumCationsCell MembraneHeLa CellsHumansMutant ProteinsORAI1 ProteinProtein BindingStromal Interaction Molecule 1TRPC Cation ChannelsCalciumCationsMutant ProteinsORAI1 ProteinStromal Interaction Molecule 1transient receptor potential cation channel, subfamily C, member 1TRPC Cation ChannelsOrai1αOrai1βSTIM1Store-operated calcium entryTRPC1

Identifiers

PMID34988680
PMCPMC8732813
OpenAlexW4206194761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.