Evidence map›Paper›PMID 34988624›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

[

Patrick Conen, Francesca Pennetta, Katharina Dendl, Fabian Hertel, Andreas Vogg, Uwe Haberkorn, Frederik L Giesel, Felix M Mottaghy

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05752097 (Clinical Study of Fibroblast Activating Protein Inhibitor), which is not on this map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05752097 unknown statusnot on this mapstarted 2023, after this paper: background citation

Clinical Study of Fibroblast Activating Protein Inhibitor (FAPI) -Mediated 18F Targeted to Evaluate Inflammation and Fibrosis in Renal Diseases

Typeobservational_patient_registrySponsorSichuan Provincial People's HospitalRan2023 to 2024Enrolled30Conditions18F-FAPI PET/CT Examination, Renal Puncture BiopsyArms[18F]AlF-NOTA-FAPI-04 PET/CT examination, Renal puncture biopsy
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Diagnostic Performance of [Diagnostics (Basel, Switzerland) · 2026
    Article
  3. European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Molecular imaging of fibroblast activation in systemic sclerosis using [European journal of nuclear medicine and molecular imaging · 2026
    Article
  8. Quantitative imaging in medicine and surgery · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Noninvasive diagnosis and classification of kidney transplantation rejection byEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  15. Total-body positron emission tomography: Investigating mechanisms in cardiovascular-kidney-metabolic syndrome.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025
    Review
  16. Efficacy of [Annals of nuclear medicine · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Patrick ConenDepartment of Nuclear Medicine, University Hospital RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Francesca PennettaDepartment of Nuclear Medicine, University Hospital RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Katharina DendlDepartment of Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Fabian HertelDepartment of Nuclear Medicine, University Hospital RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Andreas VoggDepartment of Nuclear Medicine, University Hospital RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Uwe HaberkornClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Frederik L GieselClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Felix M MottaghyDepartment of Nuclear Medicine, University Hospital RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany. fmottaghy@ukaachen.de.ORCID 0000-0002-7212-6521
University Hospital Cologne · DEGerman Cancer Research Center · DEHeidelberg University · DEMaastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeKidney fibrosis leads to a progressive reduction in kidney function ultimately resulting in kidney failure. Diagnostic tools to detect kidney fibrosis are all invasive in nature requiring kidney biopsies with subsequent histological validation. In this retrospective study, the diagnostic value of three different radiotracers for the noninvasive prediction of kidney fibrosis was analyzed, taking into account the glomerular filtration rate (GFR) and the intra-renal parenchymal radiotracer uptake.

methodsIn 81 patients receiving either one of the following molecular imaging probes, [

resultsWe found a negative correlation between GFR and [

conclusionThere is a significant negative correlation between renal parenchymal [

Indexed as

Positron Emission Tomography Computed TomographyRenal Insufficiency, ChronicBiological TransportFibrosisGallium RadioisotopesHumansRetrospective StudiesGallium RadioisotopesDOTATOC PET/CTFAPI PET/CTFibroblast-activation-proteinKidney fibrosisPSMA PET/CT

Identifiers

PMID34988624
PMCPMC9308582
OpenAlexW4205970826

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.