Evidence map›Paper›PMID 34988617›Full record

ArticleJournal of neurology2022

MRI of the intraspinal nerve roots in patients with chronic inflammatory neuropathies: abnormalities correlate with clinical phenotypes.

Marieke H J van Rosmalen, Martijn Froeling, Stefano Mandija, Jeroen Hendrikse, W Ludo van der Pol, H Stephan Goedee

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In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Marieke H J van RosmalenDepartment of Neurology and Neurosurgery, University Medical Center Utrecht, Heidelberglaan 100, 3508GA, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-3959-1373
Martijn FroelingDepartment of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3508GA, Utrecht, The Netherlands.
Stefano MandijaDepartment of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3508GA, Utrecht, The Netherlands.
Jeroen HendrikseDepartment of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3508GA, Utrecht, The Netherlands.
W Ludo van der Pol *Department of Neurology and Neurosurgery, University Medical Center Utrecht, Heidelberglaan 100, 3508GA, Utrecht, The Netherlands. w.l.vanderpol@umcutrecht.nl.
H Stephan Goedee *Department of Neurology and Neurosurgery, University Medical Center Utrecht, Heidelberglaan 100, 3508GA, Utrecht, The Netherlands.
Heidelberg University · DEUtrecht University · NL

Funding

Prinses Beatrix Spierfonds W.OR17-21
6 · The paper itself

Abstract

objectiveChronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) are caused by inflammatory changes of peripheral nerves. It is unknown if the intra-spinal roots are also affected. This MRI study systematically visualized intra-spinal nerve roots, i.e., the ventral and dorsal roots, in patients with CIDP, MMN and motor neuron disease (MND).

methodsWe performed a cross-sectional study in 40 patients with CIDP, 27 with MMN and 34 with MND. All patients underwent an MRI scan of the cervical intra-spinal roots. We systematically measured intra-spinal nerve root sizes bilaterally in the transversal plane at C5, C6 and C7 level. We calculated mean nerve root sizes and compared them between study groups and between different clinical phenotypes using a univariate general linear model.

resultsPatients with MMN and CIDP with a motor phenotype had thicker ventral roots compared to patients with CIDP with a sensorimotor phenotype (p = 0.012), while patients with CIDP with a sensory phenotype had thicker dorsal roots compared to patients with a sensorimotor phenotype (p = 0.001) and with MND (p = 0.004).

conclusionWe here show changes in the morphology of intra-spinal nerve roots in patients with chronic inflammatory neuropathies, compatible with their clinical phenotype.

Indexed as

Motor Neuron DiseasePolyneuropathiesPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingCross-Sectional StudiesHumansMagnetic Resonance ImagingPeripheral NervesPhenotypeChronic inflammatory demyelinating polyneuropathyIntradural nerve rootsIntra-spinal nerve rootsMotor neuron diseaseMRIMultifocal motor neuropathy

Identifiers

PMID34988617
OpenAlexW4205162487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.