Evidence map›Paper›PMID 34988506›Full record

ArticleHeart rhythm O22021

Arrhythmias in patients with in-hospital alcohol withdrawal are associated with increased mortality: Insights from 1.5 million hospitalizations for alcohol withdrawal syndrome.

Samarthkumar Thakkar, Harsh P Patel, Leela Krishna Teja Boppana, Mohammad Faisaluddin, Devesh Rai, Aakash R Sheth, Ashish Kumar, Fadee Kutom, Salman Zahid, Bipul Baibhav and 4 more

Open access · goldAbstract read
In one paragraph

Article in Heart rhythm O2, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Age and Sex Differences in Alcohol Withdrawal Syndrome.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026
    Article
  2. Article
  3. Electrocardiographic Changes During and After Alcohol Withdrawal.Psychiatry and clinical psychopharmacology · 2023
    Article
  4. Alcohol and Cardiac Arrythmias: A Review of the Current Data.Reviews in cardiovascular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Samarthkumar ThakkarDepartment of Internal Medicine, Rochester General Hospital, Rochester, New York.
Harsh P PatelDepartment of Internal Medicine, Louis A Weiss Memorial Hospital, Chicago, Illinois.
Leela Krishna Teja BoppanaDepartment of Internal Medicine, Rochester General Hospital, Rochester, New York.
Mohammad FaisaluddinDepartment of Internal Medicine, Rochester General Hospital, Rochester, New York.
Devesh RaiDepartment of Internal Medicine, Rochester General Hospital, Rochester, New York.
Aakash R ShethDepartment of Internal Medicine, Louisiana State University, Shreveport, Louisiana.
Ashish KumarDepartment of Internal Medicine, Cleveland Clinic Akron General, Akron, Ohio.
Fadee KutomDepartment of Internal Medicine, Louis A Weiss Memorial Hospital, Chicago, Illinois.
Salman ZahidDepartment of Internal Medicine, Rochester General Hospital, Rochester, New York.
Bipul BaibhavSands Constellation Heart Institute, Rochester Regional Health, Rochester, New York.
Sourbha S DaniDepartment of Cardiology, Lahey Hospital & Medical Center, Burlington, Massachusetts.
Mohan RaoSands Constellation Heart Institute, Rochester Regional Health, Rochester, New York.
Christopher V DeSimoneDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Abhishek DeshmukhDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Rochester General Hospital · USMayo Clinic · USUnity Health System · USWeiss Memorial Hospital · USCleveland Clinic · USLahey Medical Center · USLouisiana State University in Shreveport · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial arrhythmias are commonly noted in patients with alcohol withdrawal syndrome (AWS), requiring inpatient admission.

objectiveThe burden of arrhythmias and the association with in-hospital outcomes are incompletely defined in patients hospitalized with AWS.

methodsThe nationwide inpatient sample database was accessed from September 2015 to December 2018 to identify hospitalizations for AWS. We studied a cohort of patients with arrhythmias noted during hospitalization using the appropriate International Classification of Diseases, Tenth Revision billing codes. We compared patient characteristics, outcomes, and hospitalization costs between alcohol withdrawal hospitalizations with and without documented arrhythmias. Propensity score matching (PSM) and multivariate regression were performed to control confounders and develop odds ratios (OR), respectively.

resultsAmong 1,511,155 hospitalization with AWS, 146,825 (9.72%) had concurrent arrhythmias. After PSM, we identified 135,540 cases in each group. Hospitalizations with AWS and concurrent arrhythmias had higher in-hospital mortality (4.19% vs 1.95%, OR 1.76, confidence interval [CI] 1.67-1.85,

conclusionArrhythmia in AWS is associated with higher in-hospital mortality and poorer in-hospital outcomes.

Indexed as

Acute heart failureAcute kidney injuryAcute respiratory failureAlcohol withdrawal syndromeArrhythmiaAtrial fibrillationMortality

Identifiers

PMID34988506
PMCPMC8703122
OpenAlexW3207482583

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.