Evidence map›Paper›PMID 34988476›Full record

ArticleJACC. CardioOncology2021

Clinical, Echocardiographic, and Biomarker Associations With Impaired Cardiorespiratory Fitness Early After HER2-Targeted Breast Cancer Therapy.

Alis Bonsignore, Thomas H Marwick, Scott C Adams, Babitha Thampinathan, Emily Somerset, Eitan Amir, Mike Walker, Husam Abdel-Qadir, C Anne Koch, Heather J Ross and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. CardioOncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Alis BonsignoreFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada.
Thomas H MarwickBaker Heart and Diabetes Institute, Melbourne, Victoria, and Menzies Research Institute, Hobart, Tasmania, Australia.
Scott C AdamsFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada.
Babitha ThampinathanTed Rogers Program in Cardiotoxicity Prevention, Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Emily SomersetRogers Computational Program, Ted Rogers Centre for Heart Research, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Eitan AmirDivision of Medical Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada.
Mike WalkerTed Rogers Centre for Heart Research, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Husam Abdel-QadirTed Rogers Program in Cardiotoxicity Prevention, Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
C Anne KochRadiation Medicine Program, Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada.
Heather J RossTed Rogers Program in Cardiotoxicity Prevention, Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Anna WooTed Rogers Centre for Heart Research, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Bernd J WinterspergerJoint Department of Medical Imaging, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Mark J HaykowskyUniversity of Alberta, Faculty of Nursing, College of Health Science, Edmonton, Alberta, Canada.
Paaladinesh ThavendiranathanTed Rogers Program in Cardiotoxicity Prevention, Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
University of Toronto · CAUniversity Health Network · CAPrincess Margaret Cancer Centre · CATed Rogers Centre for Heart Research · CABaker Heart and Diabetes Institute · AUUniversity of Alberta · CAWomen's College Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiorespiratory fitness (CRF) is reduced in cancer survivors and predicts cardiovascular disease (CVD)-related and all-cause mortality. However, routine measurement of CRF is not always feasible.

objectivesThe purpose of this study was to identify clinical, cardiac biomarker, and imaging measures associated with reduced peak oxygen consumption (VO

methodsConsecutive women with early-stage HER2+ breast cancer receiving anthracyclines and trastuzumab were recruited prospectively. Within 6 ± 2 weeks of trastuzumab completion, we collected clinical information, systolic/diastolic echocardiographic measures, high-sensitivity troponin I, B-type natriuretic peptide, and VO

resultsAmong 147 patients (age 52.2 ± 9.3 years), the mean VO

conclusionsReadily available clinical measures were associated with VO

Indexed as

anthracyclinesBNP, B-type natriuretic peptidecardiopulmonary exercise testingCORE, cardio-oncology rehabilitationCPET, cardiopulmonary exercise testCRF, cardiorespiratory fitnessCTRCD, cancer therapy–related cardiac dysfunctionechocardiographyexercise trainingglobal longitudinal strainGLS, global longitudinal strainhsTnI, high-sensitivity troponin ILVEF, left ventricular ejection fractionLV, left ventricle/ventricularLVMi, left ventricular mass indextrastuzumabVO2peak, peak oxygen consumption

Identifiers

PMID34988476
PMCPMC8702792
OpenAlexW3211854376

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.