ArticleJACC. CardioOncology2021
The Role of Healthy Lifestyle in Cancer Incidence and Temporal Transitions to Cardiometabolic Disease.
Article in JACC. CardioOncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Combined lifestyle factors on mortality and cardiovascular disease among cancer survivors: a systematic review and meta-analysis of cohort studies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Health behaviors among young adult cancer survivors and the importance of task self-efficacy.Journal of cancer survivorship : research and practice · 2026Article
- Association of cancer treatment with excess heart age among five-year young breast cancer survivors.Journal of cancer survivorship : research and practice · 2026Article
- Oncologists Knowledge and Attitudes Towards Providing Dietary Guidance to Patients With Cancer.American journal of lifestyle medicine · 2026Article
- Global, regional, and national trends and inequality analysis of the total cancers and 29 cancer types from 1990 to 2021.BMC public health · 2025Article
- Diet and Prevention of Cardiovascular Disease and Cancer: JACC: CardioOncology State-of-the-Art Review.JACC. CardioOncology · 2025Review
- Taiwan Consensus for the Management of Cardiovascular Risks and Complications in Patients with Prostate Cancer.Acta Cardiologica Sinica · 2025Article
- Role of Cardiovascular Health in the Bidirectional Progression Trajectories Between Cardiovascular Disease, Type 2 Diabetes, and Cancer.Journal of the American Heart Association · 2025Article
- Combined effect of healthy lifestyles and obesity on cardiometabolic risks in Chinese rural adults.BMC public health · 2025Article
- Association of lifestyle modification with the development of cardiovascular disease in gastric cancer patients who underwent gastrectomy: A nationwide population-based study.Cancer medicine · 2024Article
- Body mass index mediates the association between plasma lipid concentrations and the prevalence of obstructive sleep apnea among US adults: a cross-sectional study.Frontiers in cardiovascular medicine · 2024Article
- Quality of Life in Female Breast Cancer Patients and Survivors in a South African Municipality.Breast cancer : basic and clinical research · 2024Article
- Therapeutic Approaches to Increase the Survival Rate of Cancer Patients in the Younger and Older Population.Current aging science · 2024Review
- Article
- Influence of poor sleep on cardiovascular disease-free life expectancy: a multi-resource-based population cohort study.BMC medicine · 2023Article
- Cardiovascular health: an important component of cancer survivorship.BMJ oncology · 2023Review
- The association between arterial stiffness and cancer occurrence: Data from Kailuan cohort study.Frontiers in cardiovascular medicine · 2023Article
- Article
- Clustering of Health Risk Behaviors in Mexican and Puerto Rican Men: Results from the Latino Men's Health Initiative.Nutrients · 2022Article
- Visceral Obesity Is Associated with Shorter Progression-Free Survival in Well-Differentiated Gastro-Entero-Pancreatic Neuroendocrine Neoplasia.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCardiometabolic disease, including cardiovascular disease (CVD) and type 2 diabetes (T2D), can result in serious late effects in patients with cancer. Preventing long-term complications in this population is an increasingly important priority in public health and clinical practice.
objectivesThe aim of this study was to investigate the role of a healthy lifestyle in the transition from a healthy status to the development of cancer and subsequent CVD and T2D.
methodsThe analysis was based on data from the UK Biobank and included 2 subsamples: a cancer-free cohort of 397,136 individuals in the general population and a cancer-prevalent cohort of 35,564 patients with cancer. All participants were 40 to 70 years of age and were free of CVD and T2D at recruitment. A healthy lifestyle that included no current smoking, regular physical activity, a healthy diet, and moderate alcohol consumption and sleep duration were included in a healthy lifestyle index (HLI).
resultsIn the cancer-free cohort, during a maximum follow-up period of 15 years, 6.38% and 4.18% of patients with cancer developed CVD and T2D, respectively. A healthy lifestyle significantly mitigated the risk for transition from cancer to subsequent CVD and T2D, with HRs per 1-point increment in HLI of 0.90 (95% CI: 0.86-0.94) and 0.84 (95% CI: 0.79-0.89), respectively. In the cancer-prevalent cohort, each 1-point increment in HLI was similarly associated with lower risk for CVD (HR: 0.90; 95% CI: 0.87-0.93) and T2D (HR: 0.87; 95% CI: 0.83-0.91) in cancer survivors.
conclusionsA healthy lifestyle is associated with a slower transition from cancer development to the subsequent development of CVD and T2D. Moreover, among patients with cancer, a healthy lifestyle is associated with lower risk for CVD and T2D. This study highlights the practical benefits of adherence to a healthy lifestyle.
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