ArticleCurrent research in physiology2021
The Impact of beta blockade on the cardio-respiratory system and symptoms during exercise.
Article in Current research in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Systematic Documentation of Physiotherapy Practice During Usual Care and High-Intensity Gait Training in Inpatient Stroke Rehabilitation.Journal of evaluation in clinical practice · 2026Article
- Multimodality Risk Stratification in Athletes With Long QT Syndrome.JACC. Case reports · 2026Article
- Feasibility of early interval training in patients recovering from heart valve surgery due to infective endocarditis.Pilot and feasibility studies · 2026Article
- Chronotropic index mediates the relationship between lower-limb loss level and 6-minute walk test performance.Frontiers in sports and active living · 2026Article
- Physical fitness and level of physical activity in adult patients with Marfan syndrome.Orphanet journal of rare diseases · 2025Article
- Neurophysiological mechanisms underlying cardiovascular adaptations to exercise: A narrative review.Physiological reports · 2025Review
- Article
- Validity of the Ekblom-Bak Cycle Ergometer Test in Patients with Cardiovascular Disease.Journal of rehabilitation medicine · 2024Article
- How to Manage Beta-Blockade in Older Heart Failure Patients: A Scoping Review.Journal of clinical medicine · 2024Article
- Development and application of a home-based exercise program for patients with cardiovascular disease: a feasibility study.BMC sports science, medicine & rehabilitation · 2024Article
- 2023 TAMIS/TSOC/TACVPR Consensus Statement for Patients with Acute Myocardial Infarction Rehabilitation.Acta Cardiologica Sinica · 2023Article
- Acute physiological responses to high-intensity interval exercise in patients with coronary artery disease.European journal of applied physiology · 2023Article
- Article
- The added value of haemoglobin to height, age, and sex to predict DLCO in subjects with preserved exercise capacity.PloS one · 2023Article
- Sixty years of the Bruce protocol: reappraising the contemporary role of exercise stress testing with electrocardiographic monitoring.Porto biomedical journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBeta blockers prolong life in patients with cardiovascular diseases. Negative chronotropic and inotropic effects carry the potential to adversely effect peripheral skeletal and airway smooth muscle contributing to further fatigue, dyspnea and exercise intolerance. RESEARCH QUESTIONS: Do beta-blockers reduce maximal power output (MPO), VO2 max, cardiorespiratory responses, increase the perceived effort required to cycle and breath during cardiopulmonary exercise tests (CPET) and limit the capacity to exercise?
methodsRetrospective observational study of subjects performing CPET to capacity from 1988 to 2012. Subjects with and without beta-blockers were compared: baseline physiological characteristics, MPO, VO
results42,771 subjects were included 7,787 were receiving beta-blocker [mean age 61 yrs, BMI 28.40 kg/m
interpretationIncreases in oxygen pulse minimize the reduction in exercise intolerance and symptom handicap associated with beta-blockers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.