ArticleNeuro-oncology advances
Homotopic functional connectivity disruptions in glioma patients are associated with tumor malignancy and overall survival.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Anomaly Detection for Structural and Functional Connectivity in Glioma Patients.NMR in biomedicine · 2026Article
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- A non-local diffusion magnetic resonance imaging tract density biomarker to stratify, predict, and interpret survival rates in human glioblastoma.Neuro-oncology · 2026Article
- Postsurgical perilesional functional connectivity predicts neurological outcome in glioma patients.Frontiers in neuroscience · 2026Article
- Changes in Somatomotor Network Connectivity Differentiate Better Versus Worse Recovery of Hand Dexterity After Brain Tumor Surgery: A Cohort Study.Neural plasticity · 2026Article
- Brain metabolic-functional (de)coupling from health to glioma dysfunction.Communications biology · 2025Article
- Structural-functional fingerprinting for abnormalities investigation in glioma patients.Scientific reports · 2025Article
- Clusterin-mediated polarization of M2 macrophages: a mechanism of temozolomide resistance in glioblastoma stem cells.Stem cell research & therapy · 2025Article
- Left-hemisphere glioma drives systematic patterns of contralesional functional connectivity.Brain communications · 2025Article
- Optimal approaches to analyzing functional MRI data in glioma patients.Journal of neuroscience methods · 2024Article
- Cognitive deficits and altered functional brain network organization in pediatric brain tumor patients.Brain imaging and behavior · 2023Article
- Predicting survival in glioblastoma with multimodal neuroimaging and machine learning.Journal of neuro-oncology · 2023Article
- Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities.Frontiers in human neuroscience · 2023Review
- Glioblastoma induces whole-brain spectral change in resting state fMRI: Associations with clinical comorbidities and overall survival.NeuroImage. Clinical · 2023Article
- Functional connectivity between tumor region and resting-state networks as imaging biomarker for overall survival in recurrent gliomas diagnosed byNeuro-oncology advancesArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundGliomas exhibit widespread bilateral functional connectivity (FC) alterations that may be associated with tumor grade. Limited studies have examined the connection-level mechanisms responsible for these effects. Given the typically strong FC observed between mirroring/homotopic brain regions in healthy subjects, we hypothesized that homotopic connectivity (HC) is altered in low-grade and high-grade glioma patients and the extent of disruption is associated with tumor grade and predictive of overall survival (OS) in a cohort of
methodsWe used a mirrored FC-derived cortical parcellation to extract blood-oxygen-level-dependent (BOLD) signals and to quantify FC differences between homotopic pairs in normal-appearing brain in a retrospective cohort of glioma patients and healthy controls.
resultsFifty-nine glioma patients (WHO grade 2,
conclusionsThese findings demonstrate an association between tumor grade and HC alterations that may underlie global FC changes and provide prognostic information.
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