Evidence map›Paper›PMID 34988449›Full record

ArticleNeuro-oncology advances

Determinants of impairments in functioning, fatigue, and participation ability in pediatric brain tumor survivors.

Emma J Verwaaijen, Coriene E Catsman-Berrevoets, Heleen Maurice-Stam, Arianne B Dessens, Richelle Waslander, Tabitha P L van den Adel, Saskia M F Pluijm, Roel E Reddingius, Erna Michiels, Marry M van den Heuvel-Eibrink and 1 more

Open access · goldAbstract read
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Emma J VerwaaijenPrincess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0003-1350-3363
Coriene E Catsman-BerrevoetsDepartment of Pediatric Neurology, Erasmus Medical Center Rotterdam - Sophia Children's Hospital, Rotterdam, the Netherlands.
Heleen Maurice-StamPrincess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Arianne B DessensDepartment of Child and Adolescent Psychiatry and Psychology Erasmus Medical Center Rotterdam - Sophia Children's Hospital, Rotterdam, the Netherlands.
Richelle WaslanderDepartment of Child and Adolescent Psychiatry and Psychology Erasmus Medical Center Rotterdam - Sophia Children's Hospital, Rotterdam, the Netherlands.
Tabitha P L van den AdelDepartment of Pediatric Physiotherapy, Erasmus Medical Center Rotterdam - Sophia Children's Hospital, Rotterdam, the Netherlands.
Saskia M F PluijmPrincess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Roel E ReddingiusPrincess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Erna MichielsPrincess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Marry M van den Heuvel-EibrinkPrincess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0002-7760-879X
Annelies HartmanDepartment of Pediatric Physiotherapy, Erasmus Medical Center Rotterdam - Sophia Children's Hospital, Rotterdam, the Netherlands.
Princess Máxima Center · NLErasmus MC - Sophia Children’s Hospital · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPediatric brain tumor survivors (PBTS) experience disease- and treatment-related sequelae. We aimed to investigate the occurrence of participation limitations, impairments in functioning, fatigue, and the association between patient, tumor- and treatment-related factors and these outcomes.

methodsChildren (4-18 years) after treatment for a brain tumor between 2005 and 2014 at the Erasmus Medical Center, Rotterdam, the Netherlands, were eligible. The parent-reported Child and Family Follow-up Survey developed to measure participation and impairments in functioning in youth with acquired brain injury, was used. Fatigue was assessed using the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale. Associations with patient, tumor- and treatment-related factors were explored using univariable analyses.

resultsNinety-one PBTS (median age: 11.3 years [range: 9.5-14.1], time since treatment: 3.9 years [range: 4-6.2]) were included (response rate: 55%). Participation limitations were reported in 53% and were associated with impairments in functioning (15-67%) (

conclusionMore than half of PBTS reported limited participation ability, which is associated with impairments in functioning and fatigue. The complication hydrocephalus seems to lead to more fatigue. Participation limitations, impairments in functioning and fatigue appear not to diminish in the longer term.

Indexed as

fatigueimpairmentsparticipationpediatric brain tumor survivors

Identifiers

PMID34988449
PMCPMC8704380
OpenAlexW3213155907

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.