ArticleClinical parkinsonism & related disorders2022
An intensive exercise-based training program reduces prefrontal activity during usual walking in patients with Parkinson's disease.
Article in Clinical parkinsonism & related disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Relationship between motor performance and cortical activity of older neurological disorder patients with dyskinesia using fNIRS: A systematic review.Frontiers in physiology · 2023Pooled it
- Prefrontal cortex activation while walking did not change but gait speed improved after a randomized physical therapy intervention.Aging clinical and experimental research · 2024Trial
- Brain markers of cognitive-motor control of gait function in Parkinson's disease: links with physical activity and aerobic fitness.Physical activity and nutrition · 2026Article
- Structural and functional brain changes following diverse exercise interventions in Parkinson's disease: an MRI-based narrative review.Physical activity and nutrition · 2026Article
- Cerebral activation following dynamic cycling in individuals with and without Parkinson's disease: an fNIRS investigation.Frontiers in human neuroscience · 2026Article
- Role of exercise in modulating prefrontal cortical activation for improved gait and cognition in Parkinson's disease patients.Physical activity and nutrition · 2024Article
- Whole-Head Functional Near-Infrared Spectroscopy as an Ecological Monitoring Tool for Assessing Cortical Activity in Parkinson's Disease Patients at Different Stages.International journal of molecular sciences · 2022Article
- Advancing rehabilitation in Parkinson's disease through virtual reality: a narrative review.Frontiers in neurologyReview
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Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionParkinson's disease (PD) leads to a progressive loss of locomotor automaticity. Consequently, PD patients rely more on executive resources for the control of gait, resulting in increased prefrontal activity while walking. Exercise-based training programs may improve automaticity of walking and reduce prefrontal activity in this population. This study aimed to assess the effect of an intensive multidisciplinary exercise-based training program on prefrontal activity and gait performance during usual walking in PD patients.
methodFourteen patients (mean age: 67 ± 9; disease duration: 6 ± 5 years; Hoehn and Yahr score: 1.9 ± 0.6) were included in this study. They were assessed in ON stage at three different times at 5-week intervals: two times before the training program (T0 and T1) and once after the training program (T2). Gait performance (stride time, speed, stride length, cadence, and their respective coefficient of variation) and cortical activity in the dorsolateral prefrontal cortex (DLPFC) using functional near infrared spectroscopy (fNIRS) were measured during usual walking.
resultsPatients had reduced cortical activity of the DLPFC at T2 compared to T1 (p = 0.003). Patients had shorter stride time at T2 compared to T1 (p = 0.025) and tended to have longer stride length at T2 than at T1 (p = 0.056).
conclusionThe training program led to positive effects on prefrontal activity and gait performance. Reduced prefrontal activity during usual walking after training program suggests that patients may have a greater reserve capacity to face more challenging walking conditions. Further studies will investigate the effect of this training on cortical activity during dual-task walking..
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