Evidence map›Paper›PMID 34988427›Full record

ArticleClinical parkinsonism & related disorders2021

High frequency of psychosis in late-stage Parkinsońs disease.

Inês Chendo, Margherita Fabbri, Catarina Godinho, Rita Moiron Simões, Catarina Severiano Sousa, Miguel Coelho, Valerie Voon, Joaquim J Ferreira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical parkinsonism & related disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Clinical trials in late-stage Parkinson's disease.Journal of Parkinson's disease · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Inês ChendoPsychiatry Department, Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal.
Margherita FabbriInstituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal.
Catarina GodinhoGrupo de Patologia Médica, Nutrição e Exercício Clínico (PaMNEC) do Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Escola Superior de Saúde Egas Moniz, Almada, Portugal.
Rita Moiron SimõesCNS - Campus Neurológico, Torres Vedras, Portugal.
Catarina Severiano SousaInstituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal.
Miguel CoelhoLaboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Valerie VoonDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Joaquim J FerreiraCNS - Campus Neurológico, Torres Vedras, Portugal.
University of Lisbon · PTEscola Superior de Saúde Egas Moniz · PTInserm · FRInstituto Superior Politécnico do Oeste · PTUniversity of Cambridge · GB

Funding

Medical Research Council MR/P008747/1
6 · The paper itself

Abstract

backgroundPsychosis is a frequent non-motor symptom in Parkinson's disease (PD). Estimates of the frequency of Parkinsońs disease psychosis (PDP) vary widely. Knowledge about the frequency and phenomenology of psychosis in late-stage (LS) PD patients is limited.This study aimed to determine the frequency of psychosis in LSPD patients through clinical diagnostic interview (CDI) (gold standard), according to NINDS/NIMH diagnostic criteria for PDP. The secondary objectives were to characterize the phenomenology, to test selected instruments and assess their adequacy in comparison to CDI, and to assess the psychiatric comorbidities.

methodsA cross-sectional study including LSPD patients (patients with ≥ 7 years from symptoms onset and Hoehn and Yahr scale score > 3 or a Schwab and England scale score < 50% in the ON condition) was conducted. Patients were subjected to psychiatric, neurological, and neuropsychological evaluations. Each patient was interviewed by a psychiatrist who performed a CDI.

results92 LSPD patients were included. 55.4% experienced psychotic symptoms according to NINDS/NIMH diagnostic criteria for PDP. Hallucinations were present in 94.1% and delusions in 29.4% of the psychotic patients. Visual hallucinations were the most common (88.23%) psychotic symptom. 72.5% of LSPD patients with psychotic symptoms had at least one comorbid psychiatric diagnosis. Lower frequency of psychosis was found when the assessment was performed only through selected instruments rather than CDI.

conclusionsA high frequency (55.4%) of psychotic symptoms and comorbid psychiatric (72.5%) diagnosis were found in LSPD patients. The use of CDI, in addition to structured scales may increase the sensitivity of detecting psychotic symptoms.

Indexed as

Late-stageParkinson’s diseasePsychiatric comorbiditiesPsychosis

Identifiers

PMID34988427
PMCPMC8710406
OpenAlexW3217421800

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.