Evidence map›Paper›PMID 34988396›Full record

ArticleiScience2021

cGMP signaling pathway that modulates NF-κB activation in innate immune responses.

Hirotaka Kanoh, Shinzo Iwashita, Takayuki Kuraishi, Akira Goto, Naoyuki Fuse, Haruna Ueno, Mariko Nimura, Tomohito Oyama, Chang Tang, Ryo Watanabe and 14 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  4. In the Brain of Phosphodiesterases: Potential Therapeutic Targets for Schizophrenia.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 2 countries.

Hirotaka KanohGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Shinzo IwashitaGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Takayuki KuraishiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Akira GotoGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Naoyuki FuseGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Haruna UenoGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Mariko NimuraGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Tomohito OyamaGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Chang TangGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Ryo WatanabeGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Aki HoriGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Yoshiki MomiuchiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Hiroki IshikawaGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Hiroaki SuzukiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Kumiko NabeGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Takeshi TakagakiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Masataka FukuzakiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Li-Li TongGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Sinya YamadaGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Yoshiteru OshimaGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Toshiro AigakiDepartment of Biological Sciences, Tokyo Metropolitan University, Tokyo 192-0397, Japan.
Julian A T DowInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Shireen-Anne DaviesInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Shoichiro KurataGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Tohoku University · JPUniversity of Glasgow · GBTokyo Metropolitan University · JP

Funding

MOLECULAR AND CELLULAR MECHANISMS OF HOST DEFENSET32AI007495 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI TAN, TSE-HUA · 1996 to 2011
$2.4M
Biotechnology and Biological Sciences Research Council BB/E011438/1NIAID NIH HHS T32 AI007495
6 · The paper itself

Abstract

The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that

Indexed as

Biological sciencesGenomicsImmune response

Identifiers

PMID34988396
PMCPMC8710550
OpenAlexW3214140977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.