Evidence map›Paper›PMID 34988269›Full record

ArticleData in brief2021

Safety and biocompatibility of a bionic eye: Imaging, intraocular pressure, and histology data.

Samuel C Eggenberger, Natalie L James, Cherry Ho, Steven S Eamegdool, Veronika Tatarinoff, Naomi A Craig, Barry S Gow, Susan Wan, Christopher W D Dodds, Donna La Hood and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Samuel C EggenbergerSchool of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, Australia.
Natalie L JamesGraduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia.
Cherry HoGraduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia.
Steven S EamegdoolSave Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health.
Veronika TatarinoffGraduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia.
Naomi A CraigGraduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia.
Barry S GowGraduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia.
Susan WanThe Westmead Institute for medical research, Westmead, Australia.
Christopher W D DoddsGraduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia.
Donna La HoodBrien Holden Vision Institute, Sydney, Australia.
Aaron GilmourSchool of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, Australia.
Shannon L DonahoeVeterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, University of Sydney, Sydney, Australia.
Mark KrockenbergerVeterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, University of Sydney, Sydney, Australia.
Krishna TumuluriSave Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health.
Melville J da CruzDepartment of Otolaryngology, Westmead Hospital, University of Sydney, Sydney, Australia.
John R GriggSave Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health.
Peter McCluskeySave Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health.
Nigel H LovellGraduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia.
Michele C MadiganSave Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health.
Adrian T FungSave Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health.
Gregg J SuaningSchool of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, Australia.
The University of Sydney · AUUNSW Sydney · AUBrien Holden Vision Institute · AUWestmead Institute for Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The data presented here are related and supplementary data to the research article "Implantation and long-term assessment of the stability and biocompatibility of a novel 98 channel suprachoroidal visual prosthesis in sheep" [1]. In Eggenberger et al., nine sheep of the Suffolk (N=2) and Dorper (N=7) breeds were implanted in the left eye with an electrically inactive, suprachoroidal retinal stimulator (Bionic Eye) for durations of up to 100 days. The surgical safety, implant stability and device biocompatibility were assessed. Intraocular pressure measurements, indirect and infrared ophthalmoscopy and optical coherence tomography were performed at fixed time points to evaluate the clinical effects of the surgery and device implantation. Post-mortem eye tissue collection and histology was performed to measure the effects of the intervention at the cellular level. The data, including a comprehensive collection of fundus, infrared, optical coherence tomography and histology images can be used as a reference for comparison with other research, for example, active retinal stimulators. Furthermore, these data can be used to evaluate the suitability of the sheep model, in particular Dorper sheep, for future research.

Indexed as

BiocompatibilityHistopathologyIntraocular pressureOpthalmoscopyRetinaVisual prosthesis

Identifiers

PMID34988269
PMCPMC8711049
OpenAlexW3216288118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.