Evidence map›Paper›PMID 34988236›Full record

ArticleOrthopaedic journal of sports medicine2021

Intrinsic Tendon Regeneration After Application of Purified Exosome Product: An In Vivo Study.

Elizabeth P Wellings, Tony Chieh-Ting Huang, Jialun Li, Timothy E Peterson, Alexander W Hooke, Andrew Rosenbaum, Chunfeng D Zhao, Atta Behfar, Steven L Moran, Matthew T Houdek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Extracellular vesicles as personalized medicine.Molecular aspects of medicine · 2023
    Review
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Elizabeth P WellingsDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Tony Chieh-Ting HuangDivision of Plastic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Jialun LiDivision of Plastic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Timothy E PetersonDepartment of Regenerative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Alexander W HookeDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Andrew RosenbaumDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Chunfeng D ZhaoDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Atta BehfarDepartment of Regenerative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Steven L MoranDivision of Plastic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Matthew T HoudekDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic · USWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTendons are primarily acellular, limiting their intrinsic regenerative capabilities. This limited regenerative potential contributes to delayed healing, rupture, and adhesion formation after tendon injury. PURPOSE: To determine if a tendon's intrinsic regenerative potential could be improved after the application of a purified exosome product (PEP) when loaded onto a collagen scaffold. STUDY

designControlled laboratory study.

methodsAn in vivo rabbit Achilles tendon model was used and consisted of 3 groups: (1) Achilles tenotomy with suture repair, (2) Achilles tenotomy with suture repair and collagen scaffold, and (3) Achilles tenotomy with suture repair and collagen scaffold loaded with PEP at 1 × 10

resultsThe load to failure and ultimate tensile stress were found to be similar across all groups (

conclusionMechanical and histologic results suggested that healing in the PEP-treated group favored intrinsic healing (absence of adhesions) while control animals and animals treated with collagen only healed primarily via extrinsic scar formation. Despite a smaller cross-sectional area, treated tendons had the same ultimate tensile stress. This pilot investigation shows promise for PEP as a means of effectively treating tendon injuries and enhancing intrinsic healing. CLINICAL RELEVANCE: The production of a cell-free, off-the-shelf product that can promote tendon regeneration would provide a viable solution for physicians and patients to enhance tendon healing and decrease adhesions as well as shorten the time required to return to work or sports.

Indexed as

exosomesgrowth factors/healing enhancementinjury preventiontendon biomechanicstendon healingtissue engineering

Identifiers

PMID34988236
PMCPMC8721391
OpenAlexW4200050780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.