ArticleAnnals of translational medicine2021
The clinical value of hematological neutrophil and monocyte parameters in the diagnosis and identification of sepsis.
Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 37 citations in OpenAlex.
- Monitoring for early prediction of gram-negative bacteremia using machine learning and hematological data in the emergency department.Communications medicine · 2025Article
- Genome-wide association analysis of neutrophil granularity identifies CDK6 as a regulator of primary granules.iScience · 2025Article
- PW-BALFC, a clinical dataset for detection and instance segmentation of bronchoalveolar lavage fluid cell.Scientific data · 2025Article
- The potential role of leukocytes cell population data (CPD) for diagnosing sepsis in adult patients admitted to the intensive care unit.Clinical chemistry and laboratory medicine · 2025Observational
- Recognize the Significance of Detecting Toxic Granules in Sepsis.Juntendo medical journal · 2025Article
- Risk factors and predictive nomogram for multi-organ failure in patients with acute kidney failure combined with severe sepsis.American journal of translational research · 2025Article
- A Secondary Retrospective Analysis of the Predictive Value of Neutrophil-Reactive Intensity (NEUT-RI) in Septic and Non-Septic Patients in Intensive Care.Diagnostics (Basel, Switzerland) · 2024Article
- The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis.Diagnostics (Basel, Switzerland) · 2024Article
- Diagnostic value of a logistic model of occupational lead poisoning using hematological parameters.The Journal of international medical research · 2023Article
- The Potential Role of Neutrophil-Reactive Intensity (NEUT-RI) in the Diagnosis of Sepsis in Critically Ill Patients: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2023Article
- The importance of morphological changes in neutrophils in the diagnosis of bacterial infections in dogs with confirmed urinary tract infections in a Veterinary Care Service, Rio de Janeiro, Brazil.Brazilian journal of veterinary medicine · 2023Article
- A new haematological model for the diagnosis and prognosis of severe community-acquired pneumonia: a single-center retrospective study.Annals of translational medicine · 2022Article
- Evaluation of the Glutaraldehyde Test as a Prognostic Indicator for Short- and Long-Term Mortality in Hospitalized Adult Cattle With and Without Sepsis.Journal of veterinary internal medicineArticle
- Role of C-reactive protein in disease progression, diagnosis and management.Discoveries (Craiova, Romania)Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is a life-threatening condition of organ dysfunction caused by the host's disordered immune response to infection. It has a high fatality rate and seriously endangers human health. Rapid and accurate treatment plays an important role in the reduction of septic mortality. This study aimed to investigate the clinical value of hematological parameters neutrophil (NEU)-X, NEU-Y, monocyte (MON)-X, and MON-Y in sepsis, and compare their values with that of with C-reactive protein (CRP).
methodsWe collected dipotassium ethylenediaminetetraacetic acid (EDTA-K2) anticoagulant blood samples from a total of 267 patients with positive bacterial culture and 260 healthy physical check-up patients. Participants were divided into three groups: a normal control group (n=260), bacterial infection group (n=196), and a sepsis group (n=71).
resultsMedian values of NEU-X, NEU-Y, MON-X, MON-Y, and CRP in the sepsis group were significantly higher than those in the control group and the bacterial infection group (P<0.0001). The area under the receiver operating characteristic curve (AUC) of NEU-X, NEU-Y, MON-X, MON-Y, and CRP for the diagnosis of sepsis was 0.751 (sensitivity 76.1%, specificity 58.2%), 0.877 (87.3%, 72.1%), 0.791 (77.6%, 65.9%), 0.695 (71.6%, 51.4%), and 0.790 (72.5%, 70.2%), respectively. In addition, blood smear examination results showed that NEU-X value was positively correlated with the degree of toxic granulation in neutrophils.
conclusionsThe parameters NEU-X, NEU-Y, and MON-X can be used as indicators for the differential diagnosis of sepsis with comparable diagnostic efficacy to CRP. Compared to CRP, these hematological parameters are easier to obtain, more convenient, and have economic benefits.
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