ArticleAnnals of translational medicine2021
Autophagy-related long non-coding RNA signature for potential prognostic biomarkers of patients with cervical cancer: a study based on public databases.
Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Vitamin D Reprograms Non-Coding RNA Networks to Block Zika Virus in Human Macrophages.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Disulfidptosis-related long non-coding RNA signature predicts the prognosis, tumor microenvironment, immunotherapy, and antitumor drug options in colon adenocarcinoma.Apoptosis : an international journal on programmed cell death · 2024Article
- The Interplay between Autophagy and Mitochondria in Cancer.International journal of molecular sciences · 2024Review
- LncRNA STARD7-AS1 suppresses cervical cancer cell proliferation while promoting autophagy by regulating miR-31-5p/TXNIP axis to inactivate the mTOR signaling.Journal of gynecologic oncology · 2024Article
- Identification of novel disulfidptosis-related lncRNA signatures to predict the prognosis and immune microenvironment of skin cutaneous melanoma patients.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Analysis of disulfidptosis- and cuproptosis-related LncRNAs in modulating the immune microenvironment and chemosensitivity in colon adenocarcinoma.IET systems biology · 2024Article
- Copper homeostasis and cuproptosis in gynecological cancers.Frontiers in cell and developmental biology · 2024Review
- Comprehensive analysis of autophagy associated genes and immune infiltrates in cervical cancer.Iranian journal of basic medical sciences · 2024Article
- Article
- Identification and validation of a cellular senescence-related lncRNA signature for prognostic prediction in patients with multiple myeloma.Cell cycle (Georgetown, Tex.) · 2023Article
- Identification and validation of N6-methyladenosine (m6A)-related lncRNAs signature for predicting the prognosis of laryngeal carcinoma, especially for smoking patients.Frontiers in genetics · 2023Article
- Anoikis-related long non-coding RNA signatures to predict prognosis and small molecular drug response in cervical cancer.Frontiers in pharmacology · 2023Article
- Identification of lncRNAs involved in response to ionizing radiation in fibroblasts of long-term survivors of childhood cancer and cancer-free controls.Frontiers in oncology · 2023Article
- Article
- Review
- Identification of mFrontiers in genetics · 2022Article
- An Independent Prognostic Model Based on Ten Autophagy-Related Long Noncoding RNAs in Pancreatic Cancer Patients.Genetics research · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetastasis and recurrence are the main causes of death from cervical cancer (CC), thus it is important to identify more effective biomarkers to improve its prognosis. The purpose of our research was to determine the potential role of autophagy-related long non-coding RNA (lncRNA) in CC and to construct an autophagy-related lncRNA signature for survival of CC.
methodsThe lncRNAs in CC were downloaded from The Cancer Genome Atlas (TCGA) database, and autophagy-related lncRNAs were identified through the co-expression of lncRNA genes and autophagy genes. Several autophagy-related lncRNAs with prognostic value (AC012306.2, AL109976.1, ATP2A1-AS1, ILF3-DT, Z83851.2, STARD7-AS1, AC099343.2, AC008771.1, DBH-AS1, and AC097468.3) were identified using univariate and multivariate Cox regression analyses and a prognostic signature was established. The signature effect was detected by univariate Cox regression analysis [hazard ratio (HR) =1.665; 95% confidence interval (CI): 1.331-2.082; P<0.001] and multivariate Cox regression analysis (HR =1.738; 95% CI: 1.359-2.223; P<0.001). A nomogram was drawn by risk score and clinical features.
resultsThe prognostic signature could predict the survival of CC by survival-receiver operating characteristic (ROC) curve [area under the curve (AUC) =0.810]. A nomogram was drawn by risk score and clinical features, and its c-index and calibration curve demonstrated that the prognostic signature could independently predict the prognosis of CC (P<0.001). Gene set enrichment analysis (GSEA) confirmed that the genes were significantly enriched in cancer- and autophagy-related pathways (P<0.05).
conclusionsThis 10 autophagy-related lncRNA signature has prognostic potential for CC. More important roles in the CC biology of these lncRNAs may be identified with further study.
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