Evidence map›Paper›PMID 34988154›Full record

ArticleAnnals of translational medicine2021

The application of transbronchial cryobiopsy in interstitial lung disease: a prospective, multicenter, real-world study.

Xiaobo Chen, Jing Li, Fengming Luo, Feng Tao, Xiaoju Zhang, Youru Wu, Ping Xu, Mingyao Ke, Fa Long, Laiyu Liu and 13 more

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03704233 (The Diagnostic Yield and Safety of Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Diseases), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03704233 unknown statusnot on this map

The Diagnostic Yield and Safety of Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Diseases: a Prospective, Multicenter, Real World Study

TypeobservationalSponsorGuangzhou Institute of Respiratory DiseaseRan2018 to 2021Enrolled350ConditionsDiffuse Parenchymal Lung DiseasesArmsTransbronchial cryobiopsy
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Yield and safety of different biopsy types in interstitial lung disease: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. A systematic review of procedural and sampling techniques for cryobiopsy in interstitial lung disease.European respiratory review : an official journal of the European Respiratory Society · 2024
    Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 20 institutions in 1 country.

Xiaobo Chen *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jing Li *Department of Respiratory and Critical Care Medicine, Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences, Guangzhou, China.
Fengming Luo *Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
Feng TaoDepartment of Respiratory and Critical Care Medicine, The First Hospital of Jiaxing/First Affiliated Hospital of Jiaxing University, Jiaxing, China.
Xiaoju ZhangDepartment of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Youru WuDepartment of Respiratory and Critical Care Medicine, Mianyang Central Hospital, Mianyang, China.
Ping XuDepartment of Respiratory and Critical Care Medicine, Peking University Shenzhen Hospital, Shenzhen, China.
Mingyao KeDepartment of Respiratory Centre, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China.
Fa LongDepartment of Pulmonary and Critical Care Medicine, University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen, China.
Laiyu LiuChronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Liping LvEndoscopy Center, Anhui Chest Hospital, Hefei, China.
Huai LiaoDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Ye GuEndoscopy Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Zhiguang LiuDepartment of Respiratory and Critical Care Medicine, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
Xiaoming TanDepartment of Respiratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Shuliang GuoDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yi HuDepartment of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huaping YangDepartment of Pulmonary and Critical Care Medicine, Xiangya Hospital Central South University, Changsha, China.
Yong ZhouCenter for Respiratory Endoscopy Diagnosis and Treatment, Xi'an Chest Hospital, Xi'an, China.
Hongmei ZhouDepartment of Pulmonary and Critical Care Medicine, Tianyou Hospital affiliated with Tongji University, Shanghai, China.
Yongshun YeDepartment of Pulmonary and Critical Care Medicine, Huizhou Municipal Central Hospital, Huizhou, China.
Difei ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Shiyue LiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xi'an Chest Hospital · CNCentral Hospital of Wuhan · CNChongqing Medical University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNFirst Hospital of Jiaxing · CNGuangdong Provincial People's Hospital · CNGuangzhou Medical University · CNHenan Provincial People's Hospital · CNHuizhou Central People's Hospital · CNHunan Provincial People's Hospital · CNMianyang Central Hospital · CNNanfang Hospital · CNPeking University Shenzhen Hospital · CNRenji Hospital · CNShanghai Pulmonary Hospital · CNSichuan University · CNState Key Laboratory of Respiratory Disease · CNSun Yat-sen University · CNThe Second Affiliated Hospital of Xiamen Medical CollegeTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransbronchial cryobiopsy (TBCB) has been widely used to diagnose interstitial lung disease (ILD). Existing reports on TBCB in ILD are mostly single-center prospective or retrospective studies but rarely multicenter prospective real-world studies. We explored the diagnostic efficiency and safety of TBCB in ILD in a real world setting.

methodsA prospective, multicenter, real-world study was conducted to analyze the data of patients with unclarified ILD who underwent TBCB in 20 hospitals in China from October 2018 to October 2019. The results of the pathological and multidisciplinary discussion (MDD) diagnosis and complications related to TBCB were then analyzed.

resultsA total of 373 patients were enrolled in this study, including 194 males and 179 females, with an average age of 52.6±12.4 years. None of the patients had severe hemorrhaging, and the incidence of pneumothorax was 4.8%. The proportions of definitive, possible, and unclassified pathological diagnoses were 62.5%, 5.6%, and 31.9%, respectively. The overall diagnostic yield of MDD was 63.5%. There were 237 patients with a definitive diagnosis of MDD and 136 patients with an unclarified MDD diagnosis. The cooling gas pressure, freezing durations, number of specimens, maximum lengths of specimens, and specimen sizes varied significantly between the definitive and unclarified MDD diagnoses.

conclusionsIn China, the application of TBCB in ILD is generally safe, and its diagnostic efficiency is acceptable. Using a 1.9-mm cryoprobe to collect five samples would achieve a better positive diagnostic rate for TBCB in ILD, without a significant increase in complication risk.

trial registrationClinicalTrials.gov; date of registration: 09/25/2018; registration number: NCT03704233; URL: clinicaltrials.gov.

Indexed as

efficiencyinterstitial lung disease (ILD)real-worldsafetyTransbronchial cryobiopsy (TBCB)

Identifiers

PMID34988154
PMCPMC8667155
OpenAlexW3206449101

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.