Evidence map›Paper›PMID 34988109›Full record

ArticleFrontiers in nutrition2021

Transcriptome Analysis Reveals the Anti-cancerous Mechanism of Licochalcone A on Human Hepatoma Cell HepG2.

Jun Wang, Bo Wei, Kiran Thakur, Chu-Yan Wang, Ke-Xin Li, Zhao-Jun Wei

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jun WangSchool of Biological Food and Environment, Hefei University, Hefei, China.
Bo WeiSchool of Biological Food and Environment, Hefei University, Hefei, China.
Kiran ThakurSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Chu-Yan WangSchool of Biological Food and Environment, Hefei University, Hefei, China.
Ke-Xin LiSchool of Biological Food and Environment, Hefei University, Hefei, China.
Zhao-Jun WeiSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Hefei University · CNNorth Minzu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma is a malignancy with a low survival rate globally, and there is imperative to unearth novel natural phytochemicals as effective therapeutic strategies. Licochalcone A is a chalcone from

Indexed as

HepG2 cellsLicochalcone Athe FoxO signaling pathwaythe MAPK signaling pathwaytranscription factortranscriptome analysis

Identifiers

PMID34988109
PMCPMC8720858
OpenAlexW4200203328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.