Evidence map›Paper›PMID 34988086›Full record

ArticleFrontiers in cell and developmental biology2021

Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human Na

Ludivine Lopez, Jérôme Montnach, Barbara Oliveira-Mendes, Kuldip Khakh, Baptiste Thomas, Sophia Lin, Cécile Caumes, Steven Wesolowski, Sébastien Nicolas, Denis Servent and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. The Chemistry and Biology of the Tetrodotoxin Natural Product Family.Angewandte Chemie (International ed. in English) · 2025
    Review
  3. Review
  4. The venom ofFrontiers in pharmacology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ludivine LopezL'institut du Thorax, INSERM, CNRS, UNIV NANTES, Nantes, France.
Jérôme MontnachL'institut du Thorax, INSERM, CNRS, UNIV NANTES, Nantes, France.
Barbara Oliveira-MendesL'institut du Thorax, INSERM, CNRS, UNIV NANTES, Nantes, France.
Kuldip KhakhXenon Pharmaceuticals, Burnaby, BC, Canada.
Baptiste ThomasSmartox Biotechnology, Saint-Egrève, France.
Sophia LinXenon Pharmaceuticals, Burnaby, BC, Canada.
Cécile CaumesSmartox Biotechnology, Saint-Egrève, France.
Steven WesolowskiXenon Pharmaceuticals, Burnaby, BC, Canada.
Sébastien NicolasL'institut du Thorax, INSERM, CNRS, UNIV NANTES, Nantes, France.
Denis ServentDépartement Médicaments et Technologies pour La Santé (DMTS), Service d'Ingénierie Moléculaire pour La Santé (SIMoS), ERL CNRS/CEA, Institut des Sciences du Vivant Frédéric Joliot, CEA, Université Paris Saclay, Gif-sur-Yvette, France.
Charles CohenXenon Pharmaceuticals, Burnaby, BC, Canada.
Rémy BéroudSmartox Biotechnology, Saint-Egrève, France.
Evelyne BenoitDépartement Médicaments et Technologies pour La Santé (DMTS), Service d'Ingénierie Moléculaire pour La Santé (SIMoS), ERL CNRS/CEA, Institut des Sciences du Vivant Frédéric Joliot, CEA, Université Paris Saclay, Gif-sur-Yvette, France.
Michel De WaardL'institut du Thorax, INSERM, CNRS, UNIV NANTES, Nantes, France.
Institut du Thorax · FRXenon Pharmaceuticals (Canada) · CATechnologies pour la Santé · FRLaboratoire d'Excellence Canaux Ioniques d'Intérêt Thérapeutique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huwentoxin-IV (HwTx-IV), a peptide discovered in the venom of the Chinese bird spider

Indexed as

automated patch-clampCyriopagopus schmidtidevelopment of pain therapeuticshuwentoxin-IV analoguesNaV1.6 and NaV1.7 channel subtypespeptide synthesisstructure-function relationship

Identifiers

PMID34988086
PMCPMC8722715
OpenAlexW4200300781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.