Evidence map›Paper›PMID 34987865›Full record

ArticleImmunometabolism2020

CD11c

Suzan Wetzels, Mitchell Bijnen, Erwin Wijnands, José van de Gaar, Andika Tan, Susan Coort, Erik A L Biessen, Casper G Schalkwijk, Kristiaan Wouters

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunometabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Suzan WetzelsDepartment of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6229 ER, the Netherlands.
Mitchell BijnenDepartment of Stromal Cell Immunobiology, Aix Marseille Univ, CNRS, INSERM, CIML, Marseille 13009, France.
Erwin WijnandsCentral Diagnostic Laboratory, Maastricht Universitair Medisch Centrum MUMC+, 6229 HX, the Netherlands.
José van de GaarDepartment of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6229 ER, the Netherlands.
Andika TanDepartment of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6229 ER, the Netherlands.
Susan CoortDepartment of Bioinformatics-BiGCaT, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht 6229 ER, the Netherlands.
Erik A L BiessenDepartment of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6229 ER, the Netherlands.
Casper G SchalkwijkDepartment of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6229 ER, the Netherlands.
Kristiaan WoutersDepartment of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6229 ER, the Netherlands.
Maastricht University · NLCentre National de la Recherche Scientifique · FRMaastricht University Medical Centre · NL

Funding

ZonMw 91612056
6 · The paper itself

Abstract

backgroundThe prevalence of obesity is rising and leads to increased morbidity and mortality. Adipose tissue inflammation, due to accumulation and activation of adipose tissue macrophages (ATMs), is a key driver of this phenomenon. Macrophages are heterogeneous cells, adapting quickly to the microenvironment, resulting in so-called M1 or M2 macrophages. In this study, we describe the dynamics and inflammatory properties of a newly identified ATM subset in obese mice.

methodsLDLR

resultsUpon HFD, there is a massive increase of ATM subsets in the adipose tissue. CD11c

conclusionsAmong M2 macrophages, a novel pro-inflammatory subset of macrophages was found based on their low level of MHC2 expression. This subset may play a role in the development of adipose tissue inflammation.

Indexed as

adipose tissue macrophagesbone marrow transplantationCD11cflow cytometryfree fatty acidsMHC2visceral adipose tissue

Identifiers

PMID34987865
PMCPMC7612162
OpenAlexW3017055327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.