Evidence map›Paper›PMID 34987748›Full record

ArticleJournal of tissue engineering

Lightwave-reinforced stem cells with enhanced wound healing efficacy.

Yu-Jin Kim, Hye Ran Jeon, Sung-Won Kim, Yeong Hwan Kim, Gwang-Bum Im, Jisoo Im, Soong Ho Um, Sung Min Cho, Ju-Ro Lee, Han Young Kim and 3 more

Abstract read
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yu-Jin KimSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea.
Hye Ran JeonDepartment of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Gangnam-gu, Seoul, Republic of Korea.
Sung-Won KimSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea.
Yeong Hwan KimSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea.
Gwang-Bum ImSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea.
Jisoo ImSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea.
Soong Ho UmSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea.
Sung Min ChoSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea.
Ju-Ro LeeCenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoungbuk-gu, Seoul, Republic of Korea.
Han Young KimDepartment of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, Gyeonggi, Republic of Korea.
Yoon Ki JoungCenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoungbuk-gu, Seoul, Republic of Korea.
Dong-Ik KimDepartment of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Gangnam-gu, Seoul, Republic of Korea.
Suk Ho BhangSchool of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea.ORCID https://orcid.org/0000-0003-3002-0590

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comprehensive research has led to significant preclinical outcomes in modified human adipose-derived mesenchymal stem cells (hADSCs). Photobiomodulation (PBM), a technique to enhance the cellular capacity of stem cells, has attracted considerable attention owing to its effectiveness and safety. Here, we suggest a red organic light-emitting diode (OLED)-based PBM strategy to augment the therapeutic efficacy of hADSCs. In vitro assessments revealed that hADSCs basked in red OLED light exhibited enhanced angiogenesis, cell adhesion, and migration compared to naïve hADSCs. We demonstrated that the enhancement of cellular capacity was due to an increased level of intracellular reactive oxygen species. Furthermore, accelerated healing and regulated inflammatory response was observed in mice transplanted with red light-basked hADSCs. Overall, our findings suggest that OLED-based PBM may be an easily accessible and attractive approach for tissue regeneration that can be applied to various clinical stem cell therapies.

Indexed as

angiogenesishuman adipose-derived stem cellsPhotobiomodulationwound healing

Identifiers

PMID34987748
PMCPMC8721371

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.