Evidence map›Paper›PMID 34987741›Full record

ArticleTherapeutic advances in hematology2021

Antibiotic use and ileocolonic immune cells in patients receiving fecal microbiota transplantation for refractory intestinal GvHD: a prospective cohort study.

Walter Spindelboeck, Bettina Halwachs, Nadine Bayer, Bianca Huber-Krassnitzer, Eduard Schulz, Barbara Uhl, Lukas Gaksch, Stefan Hatzl, Victoria Bachmayr, Lisa Kleissl and 7 more

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Randomized Double-Blind Phase II Trial of Fecal Microbiota Transplantation Versus Placebo in Allogeneic Hematopoietic Cell Transplantation and AML.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Walter SpindelboeckDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.ORCID https://orcid.org/0000-0002-6301-4675
Bettina HalwachsDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Nadine BayerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Bianca Huber-KrassnitzerDivision of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Eduard SchulzDivision of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.ORCID https://orcid.org/0000-0002-6672-4592
Barbara UhlDivision of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Lukas GakschDivision of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Stefan HatzlDivision of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Victoria BachmayrDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Lisa KleisslDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Patrizia KumpDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Alexander DeutschDivision of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Georg StaryDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Hildegard GreinixDivision of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Gregor GorkiewiczInstitute of Pathology, Medical University of Graz, Graz, Austria.
Christoph HögenauerDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
Peter NeumeisterDivision of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Medical University of Graz · ATMedical University of Vienna · ATAustrian Academy of Sciences · ATLudwig Boltzmann Institute for Rare and Undiagnosed Diseases · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTreatment-refractory, acute graft-

methodsConsecutive patients with treatment-refractory GI-GvHD were treated with up to six endoscopically applied FMTs.

resultsWe observed the response to FMT in four out of nine patients with severe, treatment refractory GI-GvHD, associated with a significant survival benefit (

conclusionThis study increases the knowledge about the crucial effects of antibiotics in patients given FMT for treatment refractory GI-GvHD and defines the characteristic alterations of ileocolonic mucosal immune cells in this setting.

Indexed as

antibioticsfecal microbiota transplantationgastrointestinal graft-versus-host diseaseregulatory T cellsT cellstype 3 innate lymphoid cells

Identifiers

PMID34987741
PMCPMC8721365
OpenAlexW4206802164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.