Evidence map›Paper›PMID 34987729›Full record

ArticleInternational journal of organ transplantation medicine2021

The Effect of Perioperative N-acetylcysteine on the Short and Long Term Outcomes in Pediatrics Undergoing Living-Donor Liver Transplantation.

F Khalili, M B Khosravi, M A Sahmeddini, M H Eghbal, K Kazemi, S Nikeghbalian, S Ghazanfar Tehran, B Khosravi

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PubMed Full text at PMC
In one paragraph

Article in International journal of organ transplantation medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

F KhaliliAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
M B KhosraviAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
M A SahmeddiniAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
M H EghbalAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
K KazemiShiraz Organ Transplant Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
S NikeghbalianShiraz Organ Transplant Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
S Ghazanfar TehranAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
B KhosraviBiostatistics Department, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIschemia-reperfusion injury during transplantation can cause post-operative graft dysfunction.

objectiveTo assess the efficacy of N-acetylcysteine in preventing hepatic ischemia-reperfusion injury and post-transplant outcomes.

methodsIn this retrospective study on pediatrics undergoing living-donor (from one of their parents) liver transplantation, N-acetylcysteine was administered to one group (n=20) after induction in the donors until graft harvest, and in the recipients during implantation, which was maintained for 19 hours. The second group (n=20) did not receive NAC. Early allograft dysfunction was determined in the presence of alanine aminotransferase or aspartate aminotransferase ≥2000 IU/L and bilirubin ≥10 mg/dL within the first 7 days, and an international normalized ratio ≥1.6 on day 7. Data were collected from a retrospectively maintained database.

resultsThe incidence of post-reperfusion syndrome was lower in N-acetylcysteine group compared with the other group (5%

conclusionPeri-operative infusion of N-acetylcysteine in both donor and recipient would effectively prevent post-reperfusion syndrome and renal insufficiency. However, it might not affect the early allograft dysfunction, ICU stay, and mortality. NAC increases the chance of re-operation due to non-surgical bleeding in the first post-operative day.

Indexed as

Ischemic-reperfusion injuryLiving donor liver transplantationN-acetylcysteine

Identifiers

PMID34987729
PMCPMC8717878
OpenAlexW3138906319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.