Evidence map›Paper›PMID 34987650›Full record

ArticleTheranostics2022

Sonobiopsy for minimally invasive, spatiotemporally-controlled, and sensitive detection of glioblastoma-derived circulating tumor DNA.

Christopher P Pacia, Jinyun Yuan, Yimei Yue, Lu Xu, Arash Nazeri, Rupen Desai, H Michael Gach, Xiaowei Wang, Michael R Talcott, Aadel A Chaudhuri and 3 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Review
  5. Review
  6. Focused ultrasound for brain metastases.Neuro-oncology advances · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Characterization of microbubble cavitation in theranostic ultrasound-mediated blood-brain barrier opening for gene delivery.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  14. Review
  15. Article
  16. Review
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  18. Article
  19. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Christopher P PaciaDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Jinyun YuanDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Yimei YueDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Lu XuDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Arash NazeriMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Rupen DesaiDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
H Michael GachDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Xiaowei WangDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Michael R TalcottDivision of Comparative Medicine, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Aadel A ChaudhuriDepartment of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO 63108, USA.
Gavin P DunnDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Eric C LeuthardtDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Hong ChenDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Washington University in St. Louis · USCenter for Innovation · USMallinckrodt (United States) · USUniversity of Illinois Chicago · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Image-guided focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)R01EB027223 · NIBIB · WASHINGTON UNIVERSITY · PI Hong Chen · 2019 to 2026
$4.3M
Focused ultrasound-enabled brain tumor liquid biopsy (FUS-LBx) supplementR01EB030102 · NIBIB · WASHINGTON UNIVERSITY · PI Hong Chen · 2020 to 2026
$4.3M
FOCUS: FUNCTIONAL OPTICAL IMAGING FEEDBACK-CONTROLLED CELLULAR-LEVEL ULTRASOUND STIMULATIONR01MH116981 · NIMH · WASHINGTON UNIVERSITY · PI CHEN, HONG · 2018 to 2021
$2.8M
Interdisciplinary Training in Cognitive, Computational and Systems Neuroscience (CCSN)T32NS115672 · NINDS · WASHINGTON UNIVERSITY · PI TODD S BRAVER, Camillo Padoa-Schioppa · 2020 to 2026
$1.8M
NCI NIH HHS P30 CA091842NIBIB NIH HHS R01 EB027223NIBIB NIH HHS R01 EB030102NIMH NIH HHS R01 MH116981NINDS NIH HHS T32 NS115672
6 · The paper itself

Abstract

Though surgical biopsies provide direct access to tissue for genomic characterization of brain cancer, they are invasive and pose significant clinical risks. Brain cancer management via blood-based liquid biopsies is a minimally invasive alternative; however, the blood-brain barrier (BBB) restricts the release of brain tumor-derived molecular biomarkers necessary for sensitive diagnosis.

Indexed as

Brain NeoplasmsGlioblastomaAnimalsBlood-Brain BarrierCell Line, TumorCirculating Tumor DNAHumansLiquid BiopsyMiceSonicationSwineCirculating Tumor DNAblood-based liquid biopsyblood-brain barrierdroplet digital PCRglioblastoma mutationImage-guided focused ultrasound

Identifiers

PMID34987650
PMCPMC8690937
OpenAlexW3212618582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.