Evidence map›Paper›PMID 34987640›Full record

ArticleTheranostics2022

Tumor-infiltrating lymphocytes are functionally inactivated by CD90+ stromal cells and reactivated by combined Ibrutinib and Rapamycin in human pleural mesothelioma.

Haitang Yang, Sabina Berezowska, Patrick Dorn, Philipp Zens, Peiru Chen, Ren-Wang Peng, Thomas M Marti, Gregor J Kocher, Ralph A Schmid, Sean R R Hall

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  5. Tumor Microenvironment in Melanoma-Characteristic and Clinical Implications.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Haitang YangDivision of General Thoracic Surgery, Bern University Hospital, Bern, Switzerland.
Sabina BerezowskaInstitute of Pathology, University of Bern, Bern, Switzerland.
Patrick DornDivision of General Thoracic Surgery, Bern University Hospital, Bern, Switzerland.
Philipp ZensInstitute of Pathology, University of Bern, Bern, Switzerland.
Peiru ChenState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing, People's Republic of China.
Ren-Wang PengDivision of General Thoracic Surgery, Bern University Hospital, Bern, Switzerland.
Thomas M MartiDivision of General Thoracic Surgery, Bern University Hospital, Bern, Switzerland.
Gregor J KocherDivision of General Thoracic Surgery, Bern University Hospital, Bern, Switzerland.
Ralph A SchmidDivision of General Thoracic Surgery, Bern University Hospital, Bern, Switzerland.
Sean R R HallDivision of General Thoracic Surgery, Bern University Hospital, Bern, Switzerland.
University of Bern · CHUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenineB7-H1 AntigenBiomarkers, TumorCD8-Positive T-LymphocytesHumansLymphocytes, Tumor-InfiltratingMesothelioma, MalignantPiperidinesSirolimusThy-1 AntigensTumor MicroenvironmentAdenineB7-H1 AntigenBiomarkers, TumorCD274 protein, humanibrutinibPiperidinesSirolimusThy-1 Antigensexhaustionmalignant pleural mesotheliomareprogramtumor-infiltrating lymphocytestumor microenvironment

Identifiers

PMID34987640
PMCPMC8690914
OpenAlexW3213906620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.