Evidence map›Paper›PMID 34987524›Full record

ArticleFrontiers in immunology2021

Adaptive Immune Response Signaling Is Suppressed in Ly6C

Pingping Yang, Qinghua Wu, Lizhe Sun, Pu Fang, Lu Liu, Yong Ji, Joon-Young Park, Xuebin Qin, Xiaofeng Yang, Hong Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Pingping YangDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Qinghua WuDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Lizhe SunCenter for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, Philadelphia, PA, United States.
Pu FangCenter for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, Philadelphia, PA, United States.
Lu LiuDepartment of Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Yong JiKey Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, China.
Joon-Young ParkCenter for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, Philadelphia, PA, United States.
Xuebin QinTulane National Primate Research Center, School of Medicine, Tulane University, Covington, LA, United States.
Xiaofeng YangCenter for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, Philadelphia, PA, United States.
Hong WangCenter for Metabolic Disease Research, Department of Cardiovascular Science, Lewis Kats School of Medicine, Temple University, Philadelphia, PA, United States.
Temple University · USNanchang University · CNNanjing Medical University · CNTulane University · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
CD40 monocyte in chronic kidney diseaseR01DK113775 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI WANG, HONG · 2017 to 2021
$3.3M
Caspase-1 activation mediates chronic kidney disease-accelerated atherosclerosisR01HL131460 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHOI, ERIC T., WANG, HONG · 2016 to 2019
$2.8M
Atherogenic roles of complement systemR01HL130233 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI QIN, XUEBIN, WANG, HONG · 2016 to 2019
$2.5M
HHcy-induced Inflammatory Monocyte and Macrophage Differentiation in DiabetesR01DK104116 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI WANG, HONG · 2015 to 2019
$2.2M
NHLBI NIH HHS R01 HL130233NHLBI NIH HHS R01 HL131460NIDDK NIH HHS R01 DK104116NIDDK NIH HHS R01 DK113775NIH HHS P51 OD011104
6 · The paper itself

Abstract

Rationale: Inflammatory monocyte (MC) subset differentiation is a major feature in tissue inflammatory and atherosclerosis. The underlying molecular mechanism remains unclear. Objective: This study aims to explore molecule targets and signaling which determinate immunological features in MC subsets. Methods and Results: Blood Ly6C Conclusions: Ly6C

Indexed as

Adaptive ImmunityAnimalsAntigens, LyApolipoproteins EAtherosclerosisCell DifferentiationCytokinesGene Expression RegulationGlucocorticoid-Induced TNFR-Related ProteinHistocompatibility AntigensHumansInflammationMacrophagesMiceMice, KnockoutMonocytesAntigens, LyApolipoproteins ECytokinesGlucocorticoid-Induced TNFR-Related ProteinHistocompatibility AntigensLy-6C antigen, mouseTnfrsf18 protein, mouseadaptive immune responseApoEatherosclerosisinflammatoryLy6C MC

Identifiers

PMID34987524
PMCPMC8721109
OpenAlexW4200456879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.