Evidence map›Paper›PMID 34987500›Full record

ReviewFrontiers in immunology2021

Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus.

Mariame Mohamed Ahamada, Yang Jia, Xiaochuan Wu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

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  19. The Multifaceted Role of Macrophages in Biology and Diseases.International journal of molecular sciences · 2025
    Review
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mariame Mohamed AhamadaDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Yang JiaDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiaochuan WuDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks almost every organ. The condition mostly happens to adults but is also found in children, and the latter have the most severe manifestations. Among adults, females, especially non-Caucasian, are mostly affected. Even if the etiology of SLE remains unclear, studies show a close relation between this disease and both genetics and environment. Despite the large number of published articles about SLE, we still do not have a clear picture of its pathogenesis, and no specific drug has been found to treat this condition effectively. The implication of macrophages in SLE development is gaining ground, and studying it could answer these gaps. Indeed, both

Indexed as

Macrophage ActivationAdultAnimalsCell PlasticityCell PolarityChildFemaleHumansLupus Erythematosus, SystemicMacrophagesMaleSex FactorsM1 macrophage polarizationM2 macrophage polarizationmacrophage activation syndrome (MAS)macrophage plasticity and polarizationsystemic lupus erythematosus

Identifiers

PMID34987500
PMCPMC8721097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.