Evidence map›Paper›PMID 34987477›Full record

ArticleFrontiers in endocrinology2021

Early Pregnancy Exposure to Rare Earth Elements and Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study.

Xiangrong Xu, Yuanyuan Wang, Na Han, Xiangming Yang, Yuelong Ji, Jue Liu, Chuyao Jin, Lizi Lin, Shuang Zhou, Shusheng Luo and 6 more

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Adverse effects and underlying mechanism of rare earth elements.Environmental health : a global access science source · 2025
    Pooled it
  2. Article
  3. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xiangrong XuDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Yuanyuan WangEnvironmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.
Na HanObstetrical Department, Tongzhou Maternal and Child Health Hospital of Beijing, Beijing, China.
Xiangming YangDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Yuelong JiDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Jue LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Chuyao JinDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Lizi LinDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Shuang ZhouDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Shusheng LuoDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Heling BaoDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Zheng LiuDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Bin WangInstitute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health and Family Planning Commission of the People's Republic of China, Beijing, China.
Lailai YanDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China.
Hai-Jun WangDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Xu MaEnvironmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The extensive use of rare earth elements (REEs) in many technologies was found to have effects on human health, but the association between early pregnancy exposure to REEs and gestational diabetes mellitus (GDM) is still unknown. Methods: This nested case-control study involved 200 pregnant women with GDM and 200 healthy pregnant women from the Peking University Birth Cohort in Tongzhou. We examined the serum concentrations of 14 REEs during early pregnancy and analyzed their associations with the risk of GDM. Results: When the elements were considered individually in the logistic regression model, no significant associations were found between REEs and GDM, after adjusting for confounding variables ( Conclusion: The study findings indicated that early pregnancy exposure to lower levels of REE mixture was associated with an increased risk of GDM, and Nd, Pr, and La exhibited the strongest effects in the mixture.

Indexed as

AdultCase-Control StudiesDiabetes, GestationalEnvironmental ExposureFemaleHumansMetals, Rare EarthPregnancyRiskMetals, Rare Earthearly pregnancygestational diabetes mellitus (GDM)rare earth elements (REEs)serumweighted quantile sum (WQS)

Identifiers

PMID34987477
PMCPMC8721846

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.