ArticleNature2022
RNA profiles reveal signatures of future health and disease in pregnancy.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06074601 (Observational Study of Pregnant People to Validate Biomarkers of Pregnancy Complication Risk), which is not on this map. Cited by 117 papers.
0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
75.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Observational Study of Pregnant People to Validate Biomarkers of Pregnancy Complication Risk
Who cites it
117 citing papers in PubMed, 190 citations in OpenAlex.
- Highly Atherogenic Lipid Particles are Associated with Preeclampsia After Successful Fertility Treatment for Obese Women who have Unexplained Infertility.Reproductive sciences (Thousand Oaks, Calif.) · 2023Trial
- Budget Impact Model of a Novel cfRNA Test-and-Treat Strategy for Preeclampsia in Advanced Maternal Age Pregnancies Compared with Current Guidelines.PharmacoEconomics - open · 2026Article
- Deconformer: efficient cell-type composition profiling of cfRNA across diverse cell types.Briefings in bioinformatics · 2026Article
- A high-throughput, end-to-end pipeline for extracellular miRNA biomarker discovery from human biofluids.Cell reports methods · 2026Article
- Context-aware monitoring: rethinking comprehensive screening in the era of AI.NPJ digital medicine · 2026Article
- Electric Field-Induced Release and Measurement Liquid Biopsy of Urinary Transcriptomics and Key Proteins from Normal and High-risk Pregnant Women.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Article
- The Pathophysiology of Spontaneous Preterm Birth: Emerging Mechanisms Reviewed by the Preterm Birth International Collaborative.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- From Cell-Free Transcriptomes to Single-Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Context-dependent features of transcriptomic landscapes in pregnant mother-neonate dyads of preeclampsia.Clinical and experimental pediatrics · 2026Article
- Machine learning-advanced hydrogel-based transcription-coupled positive-feedback CRISPR/Cas13a analysis for novel microRNA signatures in differential diagnosis of non-small cell lung cancer.Journal of nanobiotechnology · 2026Article
- Cell-Based and Cell-Free Non-Invasive Prenatal Analysis of Preeclampsia: An Updated Review of Liquid Biopsy.Biomedicines · 2026Review
- Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV.PLoS pathogens · 2026Article
- Enzymatic colorimetric encoding-based digital medicine for pancreatic cancer diagnosis.Nature communications · 2026Article
- Plasma RNA-Based Dual Screening for Early/Extreme Spontaneous Preterm Birth and Early Onset Preeclampsia to Enable Prevention.Diagnostics (Basel, Switzerland) · 2026Article
- exoRBase 3.0: an updated resource for extracellular RNAs from human biofluids.Nucleic acids research · 2026Article
- Investigation into biomarkers to predict preterm birth (INSIGHT): a longitudinal UK pregnancy cohort for spontaneous preterm birth research.Frontiers in reproductive health · 2026Article
- From virtual pregnancy to digital twin obstetrics: multimodal data integration for personalized prediction of pregnancy complications.Frontiers in medicine · 2026Review
- Flexible read-aware genotype imputation from sequence using biobank sized reference panels.Nature communications · 2025Article
- AI-Driven Advances in Women's Health Diagnostics: Current Applications and Future Directions.Diagnostics (Basel, Switzerland) · 2025Review
57 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
37 authors at 14 institutions in 4 countries.
Morten RasmussenMirvie, Inc., South San Francisco, CA, USA. morten@mirvie.com.ORCID http://orcid.org/0000-0002-2743-5683
Mitsu ReddyMirvie, Inc., South San Francisco, CA, USA.
Rory NolanMirvie, Inc., South San Francisco, CA, USA.
Joan Camunas-SolerMirvie, Inc., South San Francisco, CA, USA.
Arkady KhodurskyMirvie, Inc., South San Francisco, CA, USA.
Nikolai M SchellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
David E CantonwineBrigham and Women's Hospital, Boston, MA, USA.
Line EngelbrechtsenDepartment of Obstetrics and Gynecology, Herlev University Hospital, Herlev, Denmark.
Jia Dai MiDepartment of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, St Thomas' Hospital Campus, London, UK.ORCID http://orcid.org/0000-0001-5723-4252
Arup DuttaCenter for Public Health Kinetics, New Delhi, India.
Tiffany BrundageMirvie, Inc., South San Francisco, CA, USA.
Farooq SiddiquiMirvie, Inc., South San Francisco, CA, USA.
Mainou ThaoMirvie, Inc., South San Francisco, CA, USA.
Elaine P S GeeMirvie, Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7453-4433
Johnny LaMirvie, Inc., South San Francisco, CA, USA.
Courtney Baruch-GravettGlobal Alliance to Prevent Prematurity and Stillbirth (GAPPS), Lynnwood, WA, USA.
Mark K SantillanDepartment of Obstetrics & Gynecology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Saikat DebCenter for Public Health Kinetics, New Delhi, India.
Shaali M AmePublic Health Laboratory-Idc, Pemba, Zanzibar, Tanzania.
Said M AliPublic Health Laboratory-Idc, Pemba, Zanzibar, Tanzania.
Melanie AdkinsMichigan State University, East Lansing, MI, USA.
Mark A DePristoBigHat Biosciences, Inc., San Mateo, CA, USA.
Manfred LeeMirvie, Inc., South San Francisco, CA, USA.
Eugeni NamsaraevMirvie, Inc., South San Francisco, CA, USA.
Dorte Jensen Gybel-BraskDepartment of Obstetrics, Zealand University Hospital, Roskilde, Denmark.
Lillian SkibstedDepartment of Obstetrics, Zealand University Hospital, Roskilde, Denmark.
James A LitchGlobal Alliance to Prevent Prematurity and Stillbirth (GAPPS), Lynnwood, WA, USA.ORCID http://orcid.org/0000-0003-0570-0308
Donna A SantillanDepartment of Obstetrics & Gynecology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-6180-9714
Sunil SazawalCenter for Public Health Kinetics, New Delhi, India.
Rachel M TribeDepartment of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, St Thomas' Hospital Campus, London, UK.ORCID http://orcid.org/0000-0003-3675-9978
James M RobertsMagee-Womens Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences, Epidemiology and Clinical and Translational Research University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-2671-3207
Maneesh JainMirvie, Inc., South San Francisco, CA, USA.
Estrid HøgdallDepartment of Pathology, Herlev University Hospital, Herlev, Denmark.
Claudia HolzmanMichigan State University, East Lansing, MI, USA.
Stephen R QuakeDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1613-0809
Michal A ElovitzMirvie, Inc., South San Francisco, CA, USA. elovitz@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-7554-7180
Thomas F McElrathBrigham and Women's Hospital, Boston, MA, USA. tmcelrath@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-0857-0107
AbbVie (United States) · USHerlev Hospital · DKPublic Health Laboratory Ivo de Carneri · TZBrigham and Women's Hospital · USGlobal Alliance to Prevent Prematurity and Stillbirth · USMichigan State University · USSt Thomas' Hospital · GBUniversity of California System · USUniversity of Iowa Hospitals and Clinics · USChan Zuckerberg Initiative (United States) · USCollege of San Mateo · USStatens Serum Institut · DKUniversity of Pittsburgh · USZealand University Hospital · DK
Funding
University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI Lane Strathearn · 2021 to 2026
$8.5MVasopressin and Preeclampsia: Early Mechanisms for PreventionR01HD089940 · NICHD · UNIVERSITY OF IOWA · PI SANTILLAN, MARK K · 2019 to 2023
$1.9MNICHD NIH HHS P50 HD103556NICHD NIH HHS R01 HD089940
Abstract
Maternal morbidity and mortality continue to rise, and pre-eclampsia is a major driver of this burden
Indexed as
Cell-Free Nucleic AcidsPre-EclampsiaRNAFemaleHumansPredictive Value of TestsPregnancyRetrospective StudiesSensitivity and SpecificityCell-Free Nucleic AcidsRNA
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT06074601ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.