ArticleNature2022
Emergence of methicillin resistance predates the clinical use of antibiotics.
Open access · hybridAbstract readHistorical Article
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed
19.0field-weighted citation impact, top 1% of its field
What it found
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Who cites it
130 citing papers in PubMed, 264 citations in OpenAlex.
- Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids.Zoonoses and public health · 2026Article
- Soil management practices shape the abundance, diversity, and spread of antimicrobial resistance.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mapping the antimicrobial susceptibility of methicillin-resistantMicrobiology spectrum · 2026Article
- Methicillin-resistant Staphylococcus aureus.Nature reviews. Disease primers · 2026Review
- Using Ongoing Wildlife Surveillance Programs to Monitor Antibiotic Resistant Bacteria in the Environment.Environmental microbiology reports · 2026Article
- Uncovering an alternate pathway of antibiotic resistance in spore-forming bacteria.Nature communications · 2026Article
- Insectivores exhibit superior microbial network connectivity and elevated zoonotic risk by 2035 relative to rodents and bats.Science China. Life sciences · 2026Article
- Burn Wound Infections With Staphylococcus aureus: Clinical Characteristics and Risk Factors for Methicillin-Resistant Strains.International wound journal · 2026Article
- The ESKAPE Challenge: Understanding Resistance and Exploring Alternative Treatments.Antibiotics (Basel, Switzerland) · 2026Review
- ASP-COMPLEX: redefining antimicrobial stewardship to improve outcomes in high-risk patients with severe infections.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Review
- Evaluation of Novel Benzo-Annelated 1,4-Dihydropyridines as Potential Inhibitors of Antibacterial Efflux Pumps inInternational journal of molecular sciences · 2026Article
- Antimicrobial resistance in wildlife: detection of β-lactam/carbapenem resistance genes in European hedgehogs (Erinaceus europaeus, Linnaeus 1758) in Italy.Veterinary research communications · 2026Article
- Antimicrobial resistance risks associated with wild boar consumption and handling: knowledge, attitudes and practices in selected Italian regions.Scientific reports · 2026Article
- Clonal Diversity and Genetic Landscape of mecC-Positive S. aureus in Human Samples from Iran: First Report of CC/ST423/t742Iranian biomedical journal · 2026Article
- High Nasal Carriage of MRSA-mecC in Wild Rabbits in the Iberian Peninsula: a Wildlife Reservoir?Microbial ecology · 2026Article
- From Barns to Bushes: Exploring the ECOFF-Based Non-Wild-Type Status of Campylobacter spp. in Pets, Livestock, Synanthropic Birds and Wild Animals in Northwestern Italy.Zoonoses and public health · 2026Article
- Accumulation of antimicrobial resistance genes in wild chimpanzees.The ISME journal · 2026Article
- Zoonotic dermatophyteFrontiers in veterinary science · 2026Article
- A comprehensive review of emerging therapeutic strategies against methicillin-resistantFrontiers in microbiology · 2026Review
- Staphylococcus aureus: Antimicrobial resistance, quorum sensing, and antibiofilm approaches.European journal of microbiology & immunology · 2025Review
70 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
64 authors at 20 institutions in 15 countries.
Jesper Larsen *Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark. jrl@ssi.dk.ORCID http://orcid.org/0000-0003-0582-0457
Claire L Raisen *Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Xiaoliang BaDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3882-3585
Nicholas J SadgroveRoyal Botanic Gardens, Kew, Richmond, UK.
Guillermo F Padilla-GonzálezRoyal Botanic Gardens, Kew, Richmond, UK.ORCID http://orcid.org/0000-0002-8300-6891
Monique S J SimmondsRoyal Botanic Gardens, Kew, Richmond, UK.
Igor LoncaricInstitute of Microbiology, University of Veterinary Medicine, Vienna, Austria.
Heidrun KerschnerNational Reference Center for Antimicrobial Resistance and Nosocomial Infections, Institute for Hygiene, Microbiology and Tropical Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria.
Petra ApfalterNational Reference Center for Antimicrobial Resistance and Nosocomial Infections, Institute for Hygiene, Microbiology and Tropical Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria.
Rainer HartlNational Reference Center for Antimicrobial Resistance and Nosocomial Infections, Institute for Hygiene, Microbiology and Tropical Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria.
Ariane DeplanoNational Reference Centre-Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.
Stien VandendriesscheNational Reference Centre-Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.
Barbora Černá BolfíkováDepartment of Animal Science and Food Processing, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Prague, Czech Republic.ORCID http://orcid.org/0000-0001-8059-4889
Pavel HulvaDepartment of Zoology, Charles University, Prague, Czech Republic.
Maiken C ArendrupDepartment of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.
Rasmus K HareDepartment of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.
Céline BarnadasDepartment of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.
Marc SteggerDepartment of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.
Raphael N SieberDepartment of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.
Robert L SkovInfectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6079-5381
Andreas PetersenDepartment of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.
Øystein AngenDepartment of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.
Sophie L RasmussenDepartment of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.ORCID http://orcid.org/0000-0002-2975-678X
Carmen Espinosa-GongoraDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.ORCID http://orcid.org/0000-0002-9536-0548
Frank M AarestrupNational Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0002-7116-2723
Laura J LindholmExpert Microbiology Unit, Department of Health Security, Finnish Institute for Health and Welfare, Helsinki, Finland.
Suvi M NykäsenojaMicrobiology Unit, Finnish Food Authority, Helsinki, Finland.
Frederic LaurentBacteriology Department and French National Reference Center for Staphylococci, Hospices Civils de Lyon, University of Lyon, Lyon, France.
Karsten BeckerFriedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-6391-1341
Birgit WaltherInstitute of Microbiology and Epizootics, Veterinary Faculty, Freie Universität Berlin, Berlin, Germany.
Corinna KehrenbergInstitute for Veterinary Food Science, Justus-Liebig University Giessen, Giessen, Germany.
Christiane CunyNational Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany.
Franziska LayerNational Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany.ORCID http://orcid.org/0000-0002-4613-6478
Guido WernerNational Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany.
Wolfgang WitteNational Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany.
Ivonne StammVet Med Labor GmbH, Kornwestheim, Germany.
Paolo MoroniDipartimento di Medicina Veterinaria, Università degli Studi di Milano, Lodi, Italy.ORCID http://orcid.org/0000-0002-0974-3084
Hannah J JørgensenNorwegian Veterinary Institute, Ås, Norway.ORCID http://orcid.org/0000-0002-1788-9219
Hermínia de LencastreLaboratory of Molecular Genetics, ITQB NOVA, Oeiras, Portugal.ORCID http://orcid.org/0000-0001-6816-8932
Emilia CercenadoServicio de Microbiología, Hospital Universitario Lucus Augusti, Lugo, Spain.ORCID http://orcid.org/0000-0002-5279-3773
Fernando García-GarroteServicio de Microbiología, Hospital Universitario Lucus Augusti, Lugo, Spain.
Stefan BörjessonDepartment of Animal Health and Antimicrobial Strategies, National Veterinary Institute (SVA), Uppsala, Sweden.ORCID http://orcid.org/0000-0003-2219-2659
Sara HæggmanDepartment of Microbiology, Public Health Agency of Sweden, Solna, Sweden.
Vincent PerretenInstitute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.
Christopher J TealeDepartment of Bacteriology, Animal and Plant Health Agency, Weybridge, UK.
Andrew S WallerAnimal Health Trust, Newmarket, UK.ORCID http://orcid.org/0000-0002-7111-9549
Bruno PichonAntimicrobial Resistance and Healthcare Associated Infections Reference Unit, UK Health Security Agency, London, UK.
Martin D CurranClinical Microbiology and Public Health Laboratory, UK Health Security Agency, Addenbrooke's Hospital, Cambridge, UK.
Matthew J EllingtonClinical Microbiology and Public Health Laboratory, UK Health Security Agency, Addenbrooke's Hospital, Cambridge, UK.
John J WelchDepartment of Genetics, University of Cambridge, Cambridge, UK.
Sharon J PeacockDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-1718-2782
David J SeillyDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Fiona J E MorganDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Julian ParkhillDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-7069-5958
Nazreen F HadjirinDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Jodi A LindsayInstitute of Infection and Immunity, St George's, University of London, London, UK.
Matthew T G HoldenSchool of Medicine, University of St Andrews, St Andrews, UK.ORCID http://orcid.org/0000-0002-4958-2166
Giles F EdwardsScottish MRSA Reference Laboratory, NHS Greater Glasgow and Clyde, Stobhill Hospital, Glasgow, UK.
Geoffrey FosterSRUC Veterinary Services, Inverness, UK.ORCID http://orcid.org/0000-0002-5527-758X
Gavin K PatersonThe Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush, UK.ORCID http://orcid.org/0000-0002-1880-0095
Xavier DidelotSchool of Life Sciences and Department of Statistics, University of Warwick, Warwick, UK.ORCID http://orcid.org/0000-0003-1885-500X
Mark A HolmesDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5454-1625
Ewan M HarrisonDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2720-0507
Anders R LarsenDepartment of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.
Statens Serum Institut · DKUniversity of Cambridge · GBRobert Koch Institute · DEKrankenhaus der Elisabethinen · ATRoyal Botanic Gardens, Kew · GBAddenbrooke's Hospital · GBPublic Health Agency of Sweden · SEUniversité Libre de Bruxelles · BEAnimal and Plant Health Agency · GBAnimal Health Trust · GBComplejo Hospitalario de Salamanca · ESCzech University of Life Sciences Prague · CZFinnish Food Authority · FIFinnish Institute for Health and Welfare · FIFriedrich-Loeffler-Institut · DEHospital Universitario Lucus Augusti · ESIDEXX Laboratories (Germany) · DEJustus-Liebig-Universität Gießen · DENHS Greater Glasgow and Clyde · GBNorwegian Veterinary Institute · NO
Funding
Medical Research Council G1001787Medical Research Council MR/N002660/1Medical Research Council MR/P007201/1Medical Research Council MR/S00291X/1
Abstract
The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics
Indexed as
AnimalsAnti-Bacterial AgentsArthrodermataceaebeta-LactamsDenmarkEuropeEvolution, MolecularGeographic MappingHedgehogsHistory, 20th CenturyHumansMethicillin ResistanceMethicillin-Resistant Staphylococcus aureusNew ZealandOne HealthPenicillinsAnti-Bacterial Agentsbeta-LactamsPenicillins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.