Evidence map›Paper›PMID 34987221›Full record

ArticleNature2022

Decoding gene regulation in the fly brain.

Jasper Janssens, Sara Aibar, Ibrahim Ihsan Taskiran, Joy N Ismail, Alicia Estacio Gomez, Gabriel Aughey, Katina I Spanier, Florian V De Rop, Carmen Bravo González-Blas, Marc Dionne and 9 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 185 citations in OpenAlex.

  1. Regulatory logic of neuronal differentiation in theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Emergence Biases in Molecular Evolution.Genome biology and evolution · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Designing DNA With Tunable Regulatory Activity Using Discrete Diffusion.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 3 countries.

Jasper Janssens *VIB Center for Brain & Disease Research, Leuven, Belgium.ORCID http://orcid.org/0000-0001-9264-0782
Sara Aibar *VIB Center for Brain & Disease Research, Leuven, Belgium.ORCID http://orcid.org/0000-0001-6104-7134
Ibrahim Ihsan Taskiran *VIB Center for Brain & Disease Research, Leuven, Belgium.
Joy N IsmailVIB Center for Brain & Disease Research, Leuven, Belgium.
Alicia Estacio GomezDepartment of Life Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-6571-0757
Gabriel AugheyDepartment of Life Sciences, Imperial College London, London, UK.
Katina I SpanierVIB Center for Brain & Disease Research, Leuven, Belgium.ORCID http://orcid.org/0000-0002-1375-4157
Florian V De RopVIB Center for Brain & Disease Research, Leuven, Belgium.
Carmen Bravo González-BlasVIB Center for Brain & Disease Research, Leuven, Belgium.
Marc DionneDepartment of Life Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-8283-1750
Krista GrimesDepartment of Life Sciences, Imperial College London, London, UK.
Xiao Jiang QuanVIB Center for Brain & Disease Research, Leuven, Belgium.
Dafni PapasokratiVIB Center for Brain & Disease Research, Leuven, Belgium.
Gert HulselmansVIB Center for Brain & Disease Research, Leuven, Belgium.
Samira MakhzamiVIB Center for Brain & Disease Research, Leuven, Belgium.
Maxime De WaegeneerVIB Center for Brain & Disease Research, Leuven, Belgium.ORCID http://orcid.org/0000-0002-4535-3737
Valerie ChristiaensVIB Center for Brain & Disease Research, Leuven, Belgium.
Tony SouthallDepartment of Life Sciences, Imperial College London, London, UK.
Stein AertsVIB Center for Brain & Disease Research, Leuven, Belgium. stein.aerts@kuleuven.be.ORCID http://orcid.org/0000-0002-8006-0315
VIB-KU Leuven Center for Brain & Disease Research · BEImperial College London · GBCenter for Human Genetics · US

Funding

Medical Research Council MR/L018802/1Medical Research Council MR/L018802/2Wellcome Trust 207467/Z/17/Z
6 · The paper itself

Abstract

The Drosophila brain is a frequently used model in neuroscience. Single-cell transcriptome analysis

Indexed as

DrosophilaGene Expression RegulationAnimalsBrainGene Expression Regulation, DevelopmentalGene Regulatory NetworksTranscription FactorsTranscription Factors

Identifiers

PMID34987221
OpenAlexW4205345182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.