Evidence map›Paper›PMID 34987220›Full record

ArticleNature2022

Behavioural immune landscapes of inflammation.

Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G Aragones, Jackson Liang Yao Li, Rodrigo Madurga, José M Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca and 18 more

Abstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. A circadian checkpoint relocates neutrophils to minimize injury.The Journal of experimental medicine · 2026
    Article
  10. Article
  11. Article
  12. Acute priming using elevated fluid viscosity recovers 'bioRxiv : the preprint server for biology · 2026
    Article
  13. Comprehensive Assessment of Neutrophil Function in Autoimmune Diseases.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Georgiana Crainiciuc *Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
Miguel Palomino-Segura *Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-1614-1222
Miguel Molina-MorenoDepartment of Signal Processing and Communication, Universidad Carlos III de Madrid, Madrid, Spain.
Jon SiciliaArea of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
David G AragonesDepartment of Mathematics & MOLAB-Mathematical Oncology Laboratory, Universidad de Castilla-La Mancha, Ciudad Real, Spain.ORCID http://orcid.org/0000-0003-4035-0972
Jackson Liang Yao LiArea of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
Rodrigo MadurgaFaculty of Experimental Sciences and Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain.ORCID http://orcid.org/0000-0002-1381-2599
José M AdroverArea of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-1395-5477
Alejandra Aroca-CrevillénArea of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-2481-0863
Sandra Martin-SalamancaArea of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
Alfonso Serrano Del ValleArea of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0001-9343-1050
Sandra D CastilloEndothelial Pathobiology and Microenviroment Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7007-3155
Heidi C E WelchSignalling Programme, Babraham Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-7865-7000
Oliver SoehnleinInstitute for Experimental Pathology, Center for Molecular Biology of Inflammation, Westfälische Wilhelms-Universität, Münster, Germany.ORCID http://orcid.org/0000-0002-7854-0694
Mariona GrauperaEndothelial Pathobiology and Microenviroment Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Barcelona, Spain.ORCID http://orcid.org/0000-0003-4608-4185
Fátima Sánchez-CaboBioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
Alexander ZarbockDepartment of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Thomas E SmithgallDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-5238-3806
Mauro Di PilatoCenter for Immunology and Inflammatory Diseases at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Thorsten R MempelCenter for Immunology and Inflammatory Diseases at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0001-8635-5424
Pierre-Louis TharauxUniversité de Paris, Paris Cardiovascular Center, Inserm, Paris, France.ORCID http://orcid.org/0000-0002-6062-5905
Santiago F GonzálezInstitute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0003-4166-7664
Angel Ayuso-SacidoFaculty of Experimental Sciences and Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain.
Lai Guan NgSingapore Immunology Network (SIgN), A*STAR, Biopolis, Singapore.ORCID http://orcid.org/0000-0003-1905-3586
Gabriel F CalvoDepartment of Mathematics & MOLAB-Mathematical Oncology Laboratory, Universidad de Castilla-La Mancha, Ciudad Real, Spain.
Iván González-DíazDepartment of Signal Processing and Communication, Universidad Carlos III de Madrid, Madrid, Spain.
Fernando Díaz-de-MaríaDepartment of Signal Processing and Communication, Universidad Carlos III de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-6437-914X
Andrés HidalgoArea of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain. ahidalgo@cnic.es.ORCID http://orcid.org/0000-0001-5513-555X

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Strategies to Overcome Immune Resistance in Head and Neck CancersP01CA240239 · NCI · YALE UNIVERSITY · PI PAI, SARA ISABEL · 2019 to 2023
$8.4M
Cellular mechanisms by which exhausted T cell responses are restoredR01AI123349 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Thorsten Roman Mempel · 2017 to 2026
$4.5M
Precision Targeting of Myeloid Src-family Kinases in Acute Myelogenous LeukemiaR01CA233576 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SMITHGALL, THOMAS E. · 2019 to 2023
$2.4M
A mechanism to minimize auto-reactivity in the tissue-resident memory T cell poolR01AI163223 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MEMPEL, THORSTEN ROMAN · 2021 to 2025
$2.4M
NCI NIH HHS P01 CA240239NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA233576NIAID NIH HHS R01 AI123349NIAID NIH HHS R01 AI163223
6 · The paper itself

Abstract

Transcriptional and proteomic profiling of individual cells have revolutionized interpretation of biological phenomena by providing cellular landscapes of healthy and diseased tissues

Indexed as

InflammationLeukocytesProteomicsAnimalsCell ShapeEndotheliumMiceNeutrophilsProto-Oncogene Proteinssrc-Family KinasesProto-Oncogene Proteinsproto-oncogene proteins c-fgrsrc-Family Kinases

Identifiers

PMID34987220
PMCPMC10022527

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.