Evidence map›Paper›PMID 34987200›Full record

ArticleEye (London, England)2023

Extrascleral extension of choroidal melanoma after iodine-125 brachytherapy treatment: a case series.

Hamzah Mustak, Christopher Lo, Liza M Cohen, Annie Tran, Robert Almanzor, Tara A McCannel, Robert A Goldberg, Daniel B Rootman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hamzah MustakStein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Christopher LoStein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Liza M CohenStein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Annie TranDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Robert AlmanzorStein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Tara A McCannelStein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Robert A GoldbergStein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Daniel B RootmanStein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA. rootman@jsei.ucla.edu.
University of California, Los Angeles · USDoheny Eye Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe purpose of this study is to report cases of choroidal melanoma that developed extrascleral tumour recurrence after treatment with iodine-125 brachytherapy. SUBJECTS/

methodsIn this single-institution retrospective observational case series, all instances of biopsy-confirmed orbital melanoma after known intraocular melanoma were reviewed. Tumour characteristics, clinical course, time to recurrence, cytogenetics of initial tumour and recurrence, and presence of intraocular recurrence were documented.

resultsFive cases of orbital melanoma following treatment with plaque radiotherapy are described. Tumour staging was Ia (1), IIa (2), and IIb (2). The primary lesion in four of the five appeared to have undergone complete regression for an average of 2 years, with the orbital melanoma developing after this interval. Recurrence of the intraocular tumour was seen in conjunction with an extrascleral component in two cases. Four cases ultimately underwent enucleation or exenteration; three had evidence of direct extension of tumour through the sclera. Four cases in this series had molecular characteristics associated with high metastatic risk (three patients with monosomy 3, one with BAP1 mutation).

conclusionsHigh-risk tumour biology may predispose to late appearance of extrascleral melanoma despite optimal treatment and adequate control of the intraocular tumour. Extended follow-up with detailed orbital examination and imaging is recommended for this population.

Indexed as

BrachytherapyChoroid NeoplasmsMelanomaOrbital NeoplasmsHumansIodine RadioisotopesNeoplasm Recurrence, LocalRetrospective StudiesUveal MelanomaIodine-125Iodine Radioisotopes

Identifiers

PMID34987200
PMCPMC9873620
OpenAlexW4205191346

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.