Evidence map›Paper›PMID 34987198›Full record

ReviewEye (London, England)2022

Perspectives on diabetic retinopathy from advanced retinal vascular imaging.

Janice X Ong, Amani A Fawzi

Open access · bronzeAbstract readReview
In one paragraph

Review in Eye (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Diabetic Retinopathy-A Review.Current diabetes reviews · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023
    Review
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Janice X OngDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8018-8290
Amani A FawziDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. afawzimd@gmail.com.ORCID http://orcid.org/0000-0002-9568-3558
Northwestern University · US

Funding

Exploring the angiogenesis-to-fibrosis transition in ischemic retinopathies RenewalR01EY030121 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Amani A Fawzi · 2020 to 2026
$2.9M
Monitoring the hemodynamic response to therapy in diabetic retinopathyR01EY031815 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FAWZI, AMANI A · 2020 to 2023
$1.9M
NEI NIH HHS R01 EY030121NEI NIH HHS R01 EY031815
6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a microvascular complication of diabetes and the most common cause of acquired vision loss in adults worldwide. DR is associated with long-term chronic hyperglycaemia and its detrimental effects on the neurovascular structure and function of the retina. Direct imaging of the retinal vasculature and staging of DR has been traditionally based on fundoscopy and fluorescein angiography, which provide only 2D views of the retina, and in the case of fluorescein angiography, requires an invasive dye injection. In contrast, advanced retinal imaging modalities like optical coherence tomography angiography (OCTA) and adaptive optics (AO) are non-invasive and provide depth-resolved, 3D visualization of retinal vessel structure as well as blood flow. Recent studies utilizing these imaging techniques have shown promise in evaluating quantitative vascular parameters that correlate tightly to clinical DR staging, elucidating functional changes in early diabetes, and monitoring DR treatment response. In this article, we discuss and synthesize the results of advanced retinal imaging studies in DR and their implications for our clinical and pathophysiologic understanding of the disease. Based on the recent literature, we also propose a model to describe the differential changes in vascular structure and flow that have been described on advanced retinal imaging as DR progresses. Future studies of these imaging modalities in larger and more diverse populations, as well as corroboration with histological and functional studies, will be important to further our understanding of DR.

Indexed as

Diabetes MellitusDiabetic RetinopathyAdultFluorescein AngiographyHumansRetinaRetinal VesselsTomography, Optical Coherence

Identifiers

PMID34987198
PMCPMC8807653
OpenAlexW4205499631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.