ArticleNature chemistry2022
Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(II) carboxylates.
Article in Nature chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 211 citations in OpenAlex.
- Photochemical Reaction Discovery Enabled by the Dynamic Speciation of Copper Complexes.Angewandte Chemie (International ed. in English) · 2026Article
- Electrochemical Synthesis of Building Blocks with a Structure Inspired by Nonsteroidal Anti-Inflammatory Drugs.ACS omega · 2026Article
- Decarboxylative functionalization strategy for rapid assembly of bifunctional adamantaneChemical science · 2026Article
- From reagents to feedstocks: reprogramming heteroatom-containing molecules in modern organic synthesis.Molecular diversity · 2026Review
- Decarboxylative carbonyl alkylative amination: A general and practical strategy for aliphatic amine synthesis.Science advances · 2026Article
- Acridinium amidate as a hydrogen-bonding photocatalyst for direct decarboxylative alkylation of native carboxylic acids.Chemical science · 2026Article
- Enantioconvergent Chan-Evans-Lam C(spJournal of the American Chemical Society · 2026Article
- Mandelic Acid-Mediated Enantiomeric Enrichment of a Resorcinarene-Based Dissymmetric Coordination Capsule.Chemistry, an Asian journal · 2026Article
- Photooxidative Copper(II) Catalysis for Promoting anti-Markovnikov Hydration of Alkenes.Nature communications · 2026Article
- Photo-driven bifunctional iron-catalyzed one-pot assembling of indoles from arylamines and alkanes/carboxylic acids.Nature communications · 2026Article
- Oxygen migration into carbon-carbon single bonds by photochemical oxidation.Nature synthesis · 2026Article
- Late-stage adenine N6-alkylation of nucleos(t)ides and oligonucleotides via photoredox and copper co-catalytic decarboxylative C(sp3)-N coupling.Nature communications · 2025Article
- Carbon-Heteroatom Bond Formation via Photoinduced Decarboxylative Radical Coupling Reactions.ACS omega · 2025Review
- Photoexcited LMCT of CuNature communications · 2025Article
- Ligand-to-Metal Charge Transfer of Ag(II) CFAngewandte Chemie (International ed. in English) · 2025Article
- Mixed-Metal Ce-Zr-Mn Clusters as Photo-Catalysts for Decarboxylative Functionalization of Carboxylic Acids.Angewandte Chemie (International ed. in English) · 2025Article
- Unlocking Chromium Decarboxylative Ligand-to-Metal Charge Transfer: Efficient and Redox-Neutral Allylation of Aldehydes Using Carboxylic Acids.Journal of the American Chemical Society · 2025Article
- Open-Vessel and Scalable Synthesis of Linear and Branched Poly(meth)acrylic Acid via Light-Mediated Atom Transfer Radical Polymerization in Water.Macromolecules · 2025Article
- Preassembly-Controlled Radical Recombination at Bismuth: Decarboxylative C─N Coupling with Sulfonamides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Rapid and Scalable Synthesis of Oxazoles Directly from Carboxylic Acids.The Journal of organic chemistry · 2025Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Reactions that enable carbon-nitrogen, carbon-oxygen and carbon-carbon bond formation lie at the heart of synthetic chemistry. However, substrate prefunctionalization is often needed to effect such transformations without forcing reaction conditions. The development of direct coupling methods for abundant feedstock chemicals is therefore highly desirable for the rapid construction of complex molecular scaffolds. Here we report a copper-mediated, net-oxidative decarboxylative coupling of carboxylic acids with diverse nucleophiles under visible-light irradiation. Preliminary mechanistic studies suggest that the relevant chromophore in this reaction is a Cu(II) carboxylate species assembled in situ. We propose that visible-light excitation to a ligand-to-metal charge transfer (LMCT) state results in a radical decarboxylation process that initiates the oxidative cross-coupling. The reaction is applicable to a wide variety of coupling partners, including complex drug molecules, suggesting that this strategy for cross-nucleophile coupling would facilitate rapid compound library synthesis for the discovery of new pharmaceutical agents.
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