ArticleNeurology2022
Sex Differences in the Association Between Midlife Cardiovascular Conditions or Risk Factors With Midlife Cognitive Decline.
Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 43 citations in OpenAlex.
- Cognitive Impairment in People with Type 2 Diabetes Mellitus: Associations with Inflammatory and Vascular Markers.Annals of neurosciences · 2026Article
- Beyond Diagnosis: Characterising Symptom Profiles of Dementia in a Resource-Limited South African Clinical Setting.Healthcare (Basel, Switzerland) · 2026Article
- Sex differences in modifiable risk factors of dementia and their associations with cognition.Biology of sex differences · 2026Article
- A Longitudinal Investigation of Prediabetes, Diabetes, HbA1c and Cognitive Trajectories Among Cognitively Unimpaired Individuals.Journal of the American Geriatrics Society · 2026Article
- The longitudinal association between dyslipidemia and cognitive trajectory.Journal of Alzheimer's disease : JAD · 2025Article
- Astrocytes as Metabolic Sensors Orchestrating Energy-Driven Brain Vulnerability in Alzheimer's Disease.Journal of neurochemistry · 2025Review
- Sex differences in the impact of genetic and clinical risk factors for Alzheimer's disease in midlife.Journal of Alzheimer's disease : JAD · 2025Article
- Sex Differences in the Impact of Atherosclerotic Cardiovascular Risk Burden on Cognitive Health.Journal of the American Heart Association · 2025Article
- Modeling the importance of life exposure factors on memory performance in diverse older adults: A machine learning approach.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cardiovascular contributions to dementia: Examining sex differences and female-specific factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Temporal patterns of cognitive decline after hypertension onset among middle-aged and older adults in China.Scientific reports · 2025Article
- Modifiable Risk Factors for Cognitive Decline in Community-Dwelling Older Adults Differ by Sex and APOE4.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Latent profiles of modifiable dementia risk factors in later midlife: relationships with incident dementia, cognition, and neuroimaging outcomes.Molecular psychiatry · 2025Article
- Investigating the impact of sex and reproductive aging on latent signatures of modifiable dementia risk factors.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sex difference in language cognition in the elderly group: a near-infrared spectroscopy study.Neurophotonics · 2025Article
- Trends in mortality from Alzheimer's disease and related dementias with hyperlipidemia in the United States from 1999 to 2020-a CDC WONDER database study.Frontiers in neurology · 2025Article
- Sex Differences in the Association Between Cumulative Use of Cannabis and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults Study.Cannabis and cannabinoid research · 2024Article
- Lifetime History of Low Birth Weight Delivery and Cognitive Function in Middle-Aged Parous Women.Neurology · 2024Article
- Association between untreated and treated blood pressure levels and cognitive decline in community-dwelling middle-aged and older adults in China: a longitudinal study.Alzheimer's research & therapy · 2024Article
- Sex matters in the association between cardiovascular health and incident dementia: evidence from real world data.Alzheimer's research & therapy · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesThe prevalence of midlife cardiovascular conditions and risk factors is higher in men than women. Associations between midlife cardiovascular conditions or risk factors and midlife cognitive decline have been reported, but few studies have assessed sex differences in these associations.
methodsWe included 1,857 participants enrolled in the population-based Mayo Clinic Study of Aging who were 50 to 69 years of age at baseline. Participants were evaluated every 15 months by a coordinator, including neurologic evaluation and neuropsychological testing. The neuropsychological testing used 9 tests to calculate global cognitive and domain-specific (memory, language, executive function, and visuospatial skills)
resultsOverall, 1,465 (78.9%) participants had at least 1 cardiovascular condition or risk factor; the proportion of men was higher than women (767 [83.4%] vs 698 [74.5%], DISCUSSION: Midlife cardiovascular conditions and risk factors are associated with midlife cognitive decline. Moreover, specific cardiovascular conditions and risk factors have stronger associations with cognitive decline in midlife for women than men despite the higher prevalence of those conditions in men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.