Evidence map›Paper›PMID 34986900›Full record

ArticleBMC pharmacology & toxicology2022

The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study.

Omnia I Ismail, Eman S Shaltout, Nora Z Abdellah, Diab F Hetta, Wael M A Abd El-Ghani, Lobna A Abdelzaher, Ahmed Mohamed Mohamed Mahmoud, Asmaa M Hasan, Noha A Rashed, Noha Esmael Ebrahem

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pharmacology & toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Protective Effects ofFood science & nutrition · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Omnia I IsmailDepartment of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt. omnia.ismail@med.aun.edu.eg.ORCID https://orcid.org/0000-0002-5545-673X
Eman S ShaltoutDepartment of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.ORCID https://orcid.org/0000-0001-8963-0356
Nora Z AbdellahDepartment of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.ORCID https://orcid.org/0000-0003-1463-1009
Diab F HettaDepartment of Anesthesia and Pain Management, South East Institute, Assiut University, Assiut, 71515, Egypt.
Wael M A Abd El-GhaniDepartment of Neurosurgery, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
Lobna A AbdelzaherDepartment of Pharmacology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
Ahmed Mohamed Mohamed MahmoudDepartment of Pharmacology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
Asmaa M HasanDepartment of Neuropsychiatry, Assiut University hospital, Assiut, 71515, Egypt.
Noha A RashedDepartment of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
Noha Esmael EbrahemDepartment of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.ORCID https://orcid.org/0000-0002-1073-3959
Assiut University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPregabalin (PGB) was approved as new anti-epileptic drugs with little information about its teratogenic effect. AIM OF THE WORK: to evaluate the developmental toxicity of PGB. MATERIALS AND

methods60 pregnant albino rats were divided into three groups. PGB (500 mg/kg body weight/day) was given to group II, PGB (1250 mg/kg body weight/day) was given to Group III and no medications were given to group I. The pups were normally delivered. Liver, kidney and heart specimens were prepared for histological, immunohistochemical, and morphometric studies.

resultsA dose of 500 mg of PGB had minimal toxic effects in the form of mild collagen deposition and moderate positive caspase-3 immunoexpression. PGB dose of 1250 mg/kg induced gross toxic effects in form of degenerated cardiac myofibres, ruptured blood vessels, vacuolations in the renal cortex, fibrosis and strong positive caspase-3 immunoexpression.

conclusionPGB at dose of 500 mg/kg revealed minimal toxic changes. PGB cause embryotoxicity in a dose-dependent manner, as the higher dose induced more degenerative changes.

Indexed as

ElectronsHeartAnimalsFemaleKidneyLiverPregabalinPregnancyRatsPregabalinCaspase 3HeartKidneyLiverPregabalinTeratogenic

Identifiers

PMID34986900
PMCPMC8734350
OpenAlexW4205565726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.