Evidence map›Paper›PMID 34986851›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2022

Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease.

Ankur Pandya, Yuan-Jui Yu, Yin Ge, Eike Nagel, Raymond Y Kwong, Rafidah Abu Bakar, John D Grizzard, Alexander E Merkler, Ntobeko Ntusi, Steffen E Petersen and 12 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Correction to: J Cardiovasc Magn Reson, volume 24.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 20 institutions in 11 countries.

Ankur PandyaDepartment of Health Policy and Management, Harvard T.H. Chan School of Public Health, 718 Huntington Ave, 2nd Floor, Boston, MA, 02115, USA. anpandya@hsph.harvard.edu.
Yuan-Jui YuNational Taiwan University Hospital, Taipei, Taiwan.
Yin GeCardiovascular Division of the Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Eike NagelInstitute for Experimental and Translational Cardiovascular Imaging, DZHK (German Centre for Cardiovascular Research) Centre for Cardiovascular Imaging, Partner Site RheinMain, University Hospital Frankfurt/Main, Frankfurt am Main, Germany.
Raymond Y KwongCardiovascular Division of the Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Rafidah Abu BakarDepartment of Cardiology, National Heart Institute, Kuala Lumpur, Malaysia.
John D GrizzardDepartment of Radiology, Virginia Commonwealth University Medical Center, Main Hospital, Richmond, VA, USA.
Alexander E MerklerDepartment of Neurology, Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, NY, USA.
Ntobeko NtusiDepartment of Medicine, University of Cape Town & Groote Schuur Hospital, Cape Town, South Africa.
Steffen E PetersenWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.
Nina RashediDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Juerg SchwitterDivision of Cardiology, Cardiovascular Department, CMR Center University Hospital, Lausanne, Switzerland.
Joseph B SelvanayagamDepartment of Medicine, School of Medicine and Public Health, Flinders University, Adelaide, Australia.
James A WhiteDivision of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada.
James CarrDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Subha V RamanKrannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Orlando P SimonettiDepartments of Internal Medicine and Radiology, The Ohio State University, Columbus, OH, USA.
Chiara Bucciarelli-DucciRoyal Brompton and Harefield Hospitals, Guys' and St Thomas NHS Hospitals and School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Lilia M Sierra-GalanCardiovascular Division, Department of Cardiology, American British Cowdray Medical Center, Mexico City, Mexico.
Victor A FerrariCardiovascular Division and Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA.
Mona BhatiaDepartment of Imaging, Fortis Escorts Heart Institute, New Delhi, India.
Sebastian KelleDepartment of Internal Medicine and Cardiology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.
Brigham and Women's Hospital · USCentro Médico ABC · MXFlinders University · AUFortis Escorts Heart Institute · INGerman Centre for Cardiovascular Research · DEGoethe University Frankfurt · DEHarvard University · USIndiana University School of MedicineKing's College London · GBMayo Clinic in Arizona · USNational Heart Institute · MYNational Taiwan University Hospital · TWNewYork–Presbyterian Hospital · USNorthwestern University · USQueen Mary University of London · GBThe Ohio State University · USUniversity of Calgary · CAUniversity of Cape Town · ZAUniversity of Lausanne · CHUniversity of Pennsylvania · US

Funding

Department of Health
6 · The paper itself

Abstract

backgroundAlthough prior reports have evaluated the clinical and cost impacts of cardiovascular magnetic resonance (CMR) for low-to-intermediate-risk patients with suspected significant coronary artery disease (CAD), the cost-effectiveness of CMR compared to relevant comparators remains poorly understood. We aimed to summarize the cost-effectiveness literature on CMR for CAD and create a cost-effectiveness calculator, useable worldwide, to approximate the cost-per-quality-adjusted-life-year (QALY) of CMR and relevant comparators with context-specific patient-level and system-level inputs.

methodsWe searched the Tufts Cost-Effectiveness Analysis Registry and PubMed for cost-per-QALY or cost-per-life-year-saved studies of CMR to detect significant CAD. We also developed a linear regression meta-model (CMR Cost-Effectiveness Calculator) based on a larger CMR cost-effectiveness simulation model that can approximate CMR lifetime discount cost, QALY, and cost effectiveness compared to relevant comparators [such as single-photon emission computed tomography (SPECT), coronary computed tomography angiography (CCTA)] or invasive coronary angiography.

resultsCMR was cost-effective for evaluation of significant CAD (either health-improving and cost saving or having a cost-per-QALY or cost-per-life-year result lower than the cost-effectiveness threshold) versus its relevant comparator in 10 out of 15 studies, with 3 studies reporting uncertain cost effectiveness, and 2 studies showing CCTA was optimal. Our cost-effectiveness calculator showed that CCTA was not cost-effective in the US compared to CMR when the most recent publications on imaging performance were included in the model.

conclusionsBased on current world-wide evidence in the literature, CMR usually represents a cost-effective option compared to relevant comparators to assess for significant CAD.

Indexed as

Coronary Artery DiseaseCoronary AngiographyCost-Benefit AnalysisHumansMagnetic Resonance SpectroscopyPredictive Value of TestsCardiovascular magnetic resonanceCoronary artery diseaseCost-effectiveness

Identifiers

PMID34986851
PMCPMC8734365
OpenAlexW4206266296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.