ArticleWorld journal of surgical oncology2022
Combination of extramural venous invasion and lateral lymph node size detected with magnetic resonance imaging is a reliable biomarker for lateral lymph node metastasis in patients with rectal cancer.
Article in World journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Risk factors for lateral pelvic lymph node metastasis in patients with lower rectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- MRI assessment of extramural venous invasion in rectal cancer: a practical pictorial review.Abdominal radiology (New York) · 2026Review
- Radiomics' Role in Predicting Distant Metastases, Recurrence and Survival Outcome in Rectal Cancer: A Systematic Review.Cancers · 2026Review
- MRI-Based Morphological Features as Predictors of Clinical Outcomes in Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy: Insights from a Single-Institution Experience.Journal of clinical medicine · 2026Article
- Integrating perioperative inflammation and pathological invasiveness to predict recurrence after curative colorectal cancer surgery: a multicenter cohort study.Frontiers in oncology · 2026Article
- Machine learning to develop and validate a model for predicting the risk of lymph node metastasis in colorectal cancer patients.Frontiers in oncology · 2026Article
- Predictors of lateral lymph node metastasis and prognostic factors in patients with low rectal cancer who underwent lateral lymph node dissection without preoperative treatment.Annals of coloproctology · 2025Article
- Clinicopathological Factors and Nomogram Construction for Lymph Node Metastasis in Early-Onset Colorectal Cancer.Journal of gastrointestinal cancer · 2025Article
- MRI-based scoring systems for selective lateral lymph node dissection in locally advanced low rectal cancer after neoadjuvant chemoradiotherapy.European radiology · 2025Article
- Novel deep learning algorithm based MRI radiomics for predicting lymph node metastases in rectal cancer.Scientific reports · 2025Article
- Predictive value of magnetic resonance imaging parameters combined with tumor markers for rectal cancer recurrence risk after surgery.World journal of gastrointestinal surgery · 2025Article
- Machine learning prediction model for lateral lymph node metastasis in rectal cancer.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- A nomogram model for predicting lymph node metastasis of rectal cancer by combining preoperative magnetic resonance imaging signs and tumour markers.Polish journal of radiology · 2025Article
- Tailored resection for persistent extramural vascular invasion in locally advanced rectal cancers.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2024Article
- Identification of lateral pelvic nodes without metastasis in patients with rectal cancer treated with preoperative chemoradiotherapy or chemotherapy based on magnetic resonance imaging.Annals of gastroenterological surgery · 2024Article
- The role of lateral pelvic lymph node dissection in advanced rectal cancer: a review of current evidence and outcomes.Annals of coloproctology · 2024Review
- Article
- A combined diagnostic model including middle rectal artery visualization for predicting lateral lymph node metastasis in rectal cancer.Frontiers in physiology · 2024Article
- A novel radiomics based on multi-parametric magnetic resonance imaging for predicting Ki-67 expression in rectal cancer: a multicenter study.BMC medical imaging · 2023Article
- Predictive value of lesion morphology in rectal cancer based on MRI before surgery.BMC gastroenterology · 2023Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePathological extramural venous invasion (EMVI) is defined as the active invasion of malignant cells into veins beyond the muscularis propria in colorectal cancer. It is associated with poor prognosis and increases the risk of disease recurrence. Specific findings on MRI (termed MRI-EMVI) are reportedly associated with pathological EMVI. In this study, we aimed to identify risk factors for lateral lymph node (LLN) metastasis related to rectal cancer and to evaluate whether MRI-EMVI could be a new and useful imaging biomarker to help LLN metastasis diagnosis besides LLN size.
methodsWe investigated 67 patients who underwent rectal resection and LLN dissection for rectal cancer. We evaluated MRI-EMVI grading score and examined the relationship between MRI-EMVI and LLN metastasis.
resultsPathological LLN metastasis was detected in 18 cases (26.9%), and MRI-EMVI was observed in 32 cases (47.8%). Patients were divided into two cohorts, according to LLN metastasis. Multivariate analyses demonstrated that higher risk of LLN metastasis was significantly associated with MRI-EMVI (P = 0.0112) and a short lateral lymph node axis (≥ 5 mm) (P = 0.0002). The positive likelihood ratios of MRI-EMVI alone, LLN size alone, and the combination of both factors were 2.12, 4.84, and 16.33, respectively. Patients negative for both showed better 2-year relapse-free survival compared to other patients (84.4% vs. 62.1%, P = 0.0374).
conclusionsMRI-EMVI was a useful imaging biomarker for identifying LLN metastasis in patients with rectal cancer. The combination of MRI-EMVI and LLN size can improve diagnostic accuracy.
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