ArticleBMC ophthalmology2022
Acquired nasolacrimal duct obstruction: clinical and histological findings of 275 cases.
Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Lacrimal Sac and Nasolacrimal Duct Tumors Mimicking Chronic Inflammation: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Evaluation of inflammation-related histopathological changes in the lacrimal sac, nasal bone, and nasal mucosa in cases of primary acquired nasolacrimal duct obstruction.International ophthalmology · 2026Article
- Osteotomy Techniques in Endoscopic Dacryocystorhinostomy: A Three-Decade Comparative Cohort Study.Laryngoscope investigative otolaryngology · 2026Article
- Diagnostic utility of bony nasolacrimal duct area on computed tomography for differentiating malignant lacrimal tumors.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- The Impact of Proximal Nasolacrimal Abnormalities on the Surgical Outcomes of Punctal Stenosis.Journal of ophthalmology · 2026Article
- Association of morphologic pattern and biometric characteristics of the tear ducts in dacryostenosis.International ophthalmology · 2025Article
- Restenosis After Lacrimal Stent Intubation in a Patient With Indigo Carmine Positivity: A Case Report.Cureus · 2025Article
- Endoscopic endonasal dacryocystorhinostomy: impact of long-standing disease on surgical outcomes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Observational
- The Impact of Systemic Inflammation on Recurrence in Patients with Congenital Nasolacrimal Duct Obstruction.Journal of clinical medicine · 2024Article
- Role of paranasal abnormalities and systemic inflammation on primary acquired nasolacrimal duct obstruction.Journal of ophthalmic inflammation and infection · 2024Article
- Outcomes of Endoscopic Endonasal Dacryocystorhinostomy in Glaucoma Patients.Journal of personalized medicine · 2024Article
- Osteochodromyxoma presenting as case of congenital nasolacrimal duct obstruction.American journal of ophthalmology case reports · 2023Article
- The role of inflammatory biomarkers in predicting primary acquired nasolacrimal duct obstruction and postoperative recurrence.Nagoya journal of medical science · 2023Article
- Investigation of lacrimal sac space-occupying lesions using color doppler ultrasound, computed tomography, and computed tomography dacryocystography.International journal of ophthalmology · 2023Article
- The Role of Systemic Inflammation in Acquired Nasolacrimal Duct Obstruction.Beyoglu eye journal · 2023Article
- Endoscopic dacryocystorhinostomy with bicanalicular silicone tube intubation for treating chronic dacryocystitis secondary to nasolacrimal duct stent incarceration.International journal of ophthalmology · 2023Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcquired nasolacrimal duct obstruction is a blockage of the lacrimal outflow system usually caused by local nonspecific inflammation of the lacrimal sac and the nasolacrimal duct. However, cases exist where the primary nasolacrimal system obstruction is caused by malignancies. Our aim was to investigate lacrimal sac pathologies in patients with acquired nasolacrimal duct obstruction and compare their clinical manifestations.
methodsThis retrospective clinical study included 275 patients with acquired nasolacrimal duct obstruction who underwent external dacryocystorhinostomy and lacrimal sac biopsy. Cases were classified into tumor or nonspecific pathology groups and subdivided according to the level of inflammation. Histological and clinical data were analyzed.
resultsThree tumors (1.1%) (an adenoid cystic carcinoma, an eccrine spiradenoma and small B cell lymphoma) were diagnosed. Chronic nongranulomatous inflammation was the most common histological finding, corresponding to 194 cases (70.5%). The other 81 (29.5%) were subacute, acute forms of nongranulomatous inflammation, tumors and fibrosis cases. Epiphora with continuous purulent discharge was the most common clinical sign reported by 144 (52.4%) patients, and two (0.7%) patients had a palpable mass near the medial canthal tendon, which was identified as an eccrine spiradenoma and small B cell lymphoma. There was no significant difference in the clinical symptoms, duration or case history between the nonspecific pathology and tumor groups (p = 0.292).
conclusionsChronic nongranulomatous inflammation of the lacrimal sac was the most common finding among acquired nasolacrimal duct obstruction cases. There were no associations between the histological findings and clinical presentation. The authors recommend a lacrimal sac biopsy only in cases when a tumor is clinically suspected.
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