Evidence map›Paper›PMID 34986786›Full record

ArticleBMC infectious diseases2022

Poliovirus immunity among adults in the Democratic Republic of the Congo: a cross-sectional serosurvey.

Vivian H Alfonso, Arie Voorman, Nicole A Hoff, William C Weldon, Sue Gerber, Adva Gadoth, Megan Halbrook, Amelia Goldsmith, Patrick Mukadi, Reena H Doshi and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Population Immunity and Polio Eradication.Pathogens (Basel, Switzerland) · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Vivian H AlfonsoDepartment of Epidemiology, University of California, Los Angeles, USA.
Arie VoormanBill and Melinda Gates Foundation, Seattle, WA, USA.
Nicole A HoffDepartment of Epidemiology, University of California, Los Angeles, USA.
William C WeldonDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Sue GerberBill and Melinda Gates Foundation, Seattle, WA, USA.
Adva GadothDepartment of Epidemiology, University of California, Los Angeles, USA.
Megan HalbrookDepartment of Epidemiology, University of California, Los Angeles, USA.
Amelia GoldsmithDepartment of Epidemiology, University of California, Los Angeles, USA.
Patrick MukadiNational Institute for Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo.
Reena H DoshiDepartment of Epidemiology, University of California, Los Angeles, USA.
Guillaume Ngoie-MwambaExpanded Programme on Immunization, Kinshasa, Democratic Republic of the Congo.
Trevon L FullerCenter for Tropical Research, Institute of the Environment and Sustainability, University of California, Los Angeles, USA.
Emile Okitolonda-WemakoyKinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo.
Jean-Jacques Muyembe-TamfumNational Institute for Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo.
Anne W RimoinDepartment of Epidemiology, University of California, Los Angeles, USA. arimoin@ucla.edu.
University of California, Los Angeles · USBill & Melinda Gates Foundation · USCenters for Disease Control and Prevention · USNational Institute of Biomedical Research · CDMcKing Consulting (United States) · USMinistry of Public Health · CD

Funding

Bill and Melinda Gates Foundation OPP106684
6 · The paper itself

Abstract

backgroundVaccination efforts to eradicate polio currently focus on children under 5 years of age, among whom most cases of poliomyelitis still occur. However, in the Democratic Republic of the Congo (DRC), an outbreak of wild poliovirus type 1 occurred in 2010-2011 in which 16% of cases occurred among adults; in a related outbreak in the neighboring Republic of Congo, 75% of cases occurred among the same adult age-group. Given that infected adults may transmit poliovirus, this study was designed to assess adult immunity against polioviruses.

methodsWe assessed poliovirus seroprevalence using dried blood spots from 5,526 adults aged 15-59 years from the 2013-2014 Demographic and Health Survey in the DRC.

resultsAmong adults in the DRC, 74%, 72%, and 57% were seropositive for neutralizing antibodies for poliovirus types 1, 2, and 3, respectively. For all three serotypes, seroprevalence tended to be higher among older age groups, those living in households with more children, and among women.

conclusionsProtection against poliovirus is generally low among adults in the DRC, particularly for type 3 poliovirus. The lack of acquired immunity in adults suggests a potentially limited poliovirus circulation over the lifetime of those surveyed (spanning 1954 through 2014) and transmission of vaccine-derived poliovirus in this age group while underscoring the risk of these outbreaks among adults in the DRC.

Indexed as

PoliomyelitisPoliovirusAdultAgedChildChild, PreschoolCross-Sectional StudiesDemocratic Republic of the CongoDisease OutbreaksFemaleHumansInfantPoliovirus Vaccine, OralSeroepidemiologic StudiesPoliovirus Vaccine, OralAdult immunityDemocratic Republic of the CongoDemographic and Health SurveyImmunizationPolioPoliovirusVaccine-preventable diseases

Identifiers

PMID34986786
PMCPMC8728990
OpenAlexW4206448339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.