Evidence map›Paper›PMID 34986742›Full record

ArticleBioengineered2022

DNA methylation across the tree of life, from micro to macro-organism.

Nasrullah, Abrar Hussain, Sagheer Ahmed, Mahmood Rasool, Abdul Jabbar Shah

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. DNA Methylation-Associated Epigenetic Changes in Thermotolerance ofInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Unveiling Hidden Allies: In Silico Discovery of Prophages inAntibiotics (Basel, Switzerland) · 2024
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

NasrullahCenter for Advanced Studies in Vaccinology & Biotechnology (Casvab), University of Baluchistan, Quetta- Pakistan. E-mails: nasrullahkakar007@gmail.com.ORCID 0000-0001-9523-2602
Abrar HussainDepartment of Biotechnology, Faculty of Life Sciences, Buitems, Quetta-Pakistan. E-mails: Abrarbangash176@hotmail.com.ORCID 0000-0002-7646-5643
Sagheer AhmedDepartment of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan. E-mails: Sagheer.scps@stmu.edu.pk.ORCID 0000-0003-1560-7588
Mahmood RasoolCenter of Excellence in Genomic Medicine Research, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. E-mails: Mahmoodrasool@yahoo.com.ORCID 0000-0003-2997-5891
Abdul Jabbar ShahDepartment of Pharmaceutical Sciences, Comsats University, Abbottabad. E-mails: Jabbarshah@cuiatd.edu.pk.
Balochistan University of Information Technology, Engineering and Management Sciences · PKCOMSATS University Islamabad · PKKing Abdulaziz University · SAShifa Tameer-e-Millat University · PKUniversity of Balochistan · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation is a process in which methyl (CH3) groups are added to the DNA molecule. The DNA segment does not change in the sequence, but DNA methylation could alter the action of DNA. Different enzymes like DNA methyltransferases (DNMTs) take part in methylation of cytosine/adenine nucleosides in DNA. In prokaryotes, DNA methylation is performed to prevent the attack of phage and also plays a role in the chromosome replication and repair. In fungi, DNA methylation is studied to see the transcriptional changes, as in insects, the DNA methylation is not that well-known, it plays a different role like other organisms. In mammals, the DNA methylation is related to different types of cancers and plays the most important role in the placental development and abnormal DNA methylation connected with diseases like cancer, autoimmune diseases, and rheumatoid arthritis.

Indexed as

DNA MethylationAnimalsBacteriaDNAEpigenesis, GeneticFungiGenetic Predisposition to DiseaseHumansInsectaPlantsDNACpGDNA methylationepigeneticsmethyltransferases

Identifiers

PMID34986742
PMCPMC8805842
OpenAlexW4206204640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.