ArticleThe Journal of international medical research2022
Type B lactic acidosis associated with diffuse large B-cell lymphoma and the Warburg effect.
Article in The Journal of international medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- T-cell lymphoblastic lymphoma presenting with type B lactic acidosis and acute kidney injury in an adolescent.Pediatric nephrology (Berlin, Germany) · 2026Article
- Metabolic reprogramming in tumor-associated cells of hematologic malignancies: mechanisms, crosstalk networks, and therapeutic implications in the tumor microenvironment.Frontiers in immunology · 2026Review
- Persistent lactic acidosis in ALK-positive anaplastic large cell lymphoma: a case report and literature review.Frontiers in oncology · 2026Article
- Glycolysis-Driven Immune Subtypes in the Tumor Microenvironment Determine Clinical Outcomes in Diffuse Large B-Cell Lymphoma.Cancers · 2025Article
- Lactic acidosis as the initial presentation of lymphoma: A case report and integrated analysis of clinical characteristics and prognostic factors.Annals of hematology · 2025Review
- Refractory Hypoglycemia Secondary to the Warburg Effect in Diffuse Large B-Cell Lymphoma.JCEM case reports · 2025Article
- Successful management of type B lactic acidosis in metastatic cervical neuroendocrine carcinoma: A case report.Oncology letters · 2025Article
- Metabolic-immune axis in the tumor microenvironment: a new strategy for prognostic assessment and precision therapy in DLBCL and FL.Frontiers in immunology · 2025Review
- Cancer's Metabolic Hijack: The Under-Recognized Hematologic Emergency Related to the Warburg Effect.Cureus · 2025Article
- Severe hyperlactatemia in the emergency department: clinical characteristics, etiology and mortality.BMC emergency medicine · 2024Article
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- Article
- How lactate affects immune strategies in lymphoma.Frontiers in molecular biosciences · 2024Review
- B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure.BMJ case reports · 2023Article
- Article
- Type B Lactic Acidosis in a Patient with Mantle Cell Lymphoma.Case reports in critical care · 2023Article
- An Oncological Emergency: Severe Type B Lactic Acidosis From Warburg Effect in Diffuse Large B-cell Lymphoma.Cureus · 2022Article
- Association of globulin concentrations with prognosis in horses with lymphoma.Frontiers in veterinary science · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type B lactic acidosis is a rare complication of non-tissue perfusion abnormalities caused by solid tumors or hematologic malignancies. Herein, we present the case of a 42-year-old man with type B lactic acidosis and hypoglycemia who was found to have a diffuse large B-cell lymphoma. The cause of lactic acidosis and/or hypoglycemia is thought to be the Warburg effect, which is when the metabolic rate of a rapidly growing malignant tumor is very high and dominated by glycolysis. Systemic damage from type B lactic acidosis can occur when the increased rate of glycolysis exceeds the normal muscle and liver lactic acid clearance rate. The Warburg effect is a rare but serious condition that needs to be recognized, not only in diffuse large B-cell lymphoma, but also in other malignancies. The prognosis of lactic acidosis in patients with malignant tumors is very poor. Currently, effective chemotherapy seems to be the only hope for survival.
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