ArticleAmerican journal of Alzheimer's disease and other dementias
Perceived Stress in Older Dementia Caregivers: Mediation by Loneliness and Depression.
Article in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06364228 (Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Technology-Based Counselling for People with Dementia and Their Informal Carers: A Systematic Review and Meta-Analysis.Journal of Alzheimer's disease : JAD · 2023Pooled it
- Mindfulness and rumination: stress pathways for caregivers of persons living with dementia.The Gerontologist · 2026Trial
- Sequential mediation of social resources, affiliate stigma, loneliness, and positive aspects of caregiving among Chinese and Korean American dementia caregivers.International journal of nursing sciences · 2026Article
- Loneliness in caregivers of people with chronic illnesses: conceptual analysis according to Walker and Avant.Revista brasileira de enfermagem · 2026Article
- Determinants of Spousal Loneliness Among Caregivers for Patients with Proliferative Diabetic Retinopathy: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2026Article
- Meaning of informal caregivers in the care of people with chronic conditions.Revista brasileira de enfermagem · 2026Article
- Large language models for late-life depression: a blinded benchmark of clinical safety, geriatric appropriateness, and triage.Frontiers in psychiatry · 2026Article
- Friendship and momentary loneliness in dementia caregiving: daily experiences of caregivers with high and low burden.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Heightened risk: Childhood trauma and anticipatory grief exacerbate the impact of loneliness on depressive symptoms and LPS-stimulated cytokines in dementia caregivers.Psychoneuroendocrinology · 2025Article
- A Process Evaluation of the UK Randomised Trial Evaluating 'iSupport', an Online e-Health Intervention for Adult Carers of People Living with Dementia.Behavioral sciences (Basel, Switzerland) · 2025Article
- Development of a Mindfulness and Self-compassion (MASC) Stress Reduction Program for Caregivers of Persons With Dementia With Behavioral Symptoms.The Gerontologist · 2025Article
- Loneliness among dementia caregivers: evaluation of the psychometric properties and cutoff score of the Three-item UCLA Loneliness Scale.Frontiers in psychiatry · 2025Article
- Financial train, health behaviors, and psychological well-being of family caregivers of older adults during the COVID-19 pandemic.PEC innovation · 2024Article
- Social and Mental Health Factors Involved in the Severity of Loneliness in Older Individuals in a Spanish Rural Area.Nursing reports (Pavia, Italy) · 2024Article
- Behavioral and Psychological Symptoms of Dementia: Prevalence, Symptom Severity, and Caregiver Distress in South-Western Uganda-A Quantitative Cross-Sectional Study.International journal of environmental research and public health · 2023Article
- Mindfulness and Care Experience in Family Caregivers of Persons Living with Dementia.Journal of Alzheimer's disease reports · 2023Article
- Mental states in caregivers toward people with Alzheimer's disease at different stages.Frontiers in neurology · 2023Article
- The Burden of Next-of-Kin Carers of Dementia Sufferers in the Home Environment.Healthcare (Basel, Switzerland) · 2022Article
- Perceived stress and life satisfaction among elderly migrants in China: A moderated mediation model.Frontiers in psychology · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Coupled with aging, chronic stress experienced by dementia caregivers often leads to deteriorating health. Comparing caregivers and non-caregivers, we tested whether depression and loneliness mediate the relationship between caregiver status and a measure of chronic stress, the Perceived Stress Scale. Seventy-six cognitively normal older adults (mean age 72.7) were identified as caregivers or non-caregivers based on the functional independence of a paired family member. Caregivers reported more perceived stress, depression, and loneliness than non-caregivers. Using multiple mediation analyses, we found that loneliness and depression mediated the relationship of caregiver status with perceived stress. The loneliness effect on perceived stress was both direct and via its relationship with depressive symptoms. The findings suggest loneliness as a likely point of intervention to reduce caregiver stress. Initiatives to enable caregivers to maintain or develop social relationships apart from caregiver responsibilities may mitigate stress and its negative impact on mental and physical health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.