Evidence map›Paper›PMID 34986598›Full record

ArticleNucleic acids research2022

ECO: the Evidence and Conclusion Ontology, an update for 2022.

Suvarna Nadendla, Rebecca Jackson, James Munro, Federica Quaglia, Bálint Mészáros, Dustin Olley, Elizabeth T Hobbs, Stephen M Goralski, Marcus Chibucos, Christopher John Mungall and 3 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Enhancing the SIB Literature Services (SIBiLS) with annotations to support biocuration.Database : the journal of biological databases and curation · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Xenbase: A Guide to the Xenopus Genetics and Genomics Knowledgebase.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  9. The EcoCyc database (2025).EcoSal Plus · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. CardioHotspots: a database of mutational hotspots for cardiac disorders.Database : the journal of biological databases and curation · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Suvarna NadendlaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Rebecca JacksonInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-4871-5569
James MunroInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3067-6434
Federica QuagliaInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR-IBIOM), Bari, Italy.ORCID 0000-0002-0341-4888
Bálint MészárosStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.ORCID 0000-0003-0919-4449
Dustin OlleyInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-8685-0839
Elizabeth T HobbsDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland, United States.
Stephen M GoralskiDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland, United States.
Marcus ChibucosInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-9586-0780
Christopher John MungallDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Lab, Berkeley, California, USA.ORCID 0000-0002-6601-2165
Silvio C E TosattoDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID 0000-0003-4525-7793
Ivan ErillDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland, United States.ORCID 0000-0002-7280-7191
Michelle G GiglioInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-7628-5565

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Evidence and Conclusion Ontology (ECO) is a community resource that provides an ontology of terms used to capture the type of evidence that supports biomedical annotations and assertions. Consistent capture of evidence information with ECO allows tracking of annotation provenance, establishment of quality control measures, and evidence-based data mining. ECO is in use by dozens of data repositories and resources with both specific and general areas of focus. ECO is continually being expanded and enhanced in response to user requests as well as our aim to adhere to community best-practices for ontology development. The ECO support team engages in multiple collaborations with other ontologies and annotating groups. Here we report on recent updates to the ECO ontology itself as well as associated resources that are available through this project. ECO project products are freely available for download from the project website (https://evidenceontology.org/) and GitHub (https://github.com/evidenceontology/evidenceontology). ECO is released into the public domain under a CC0 1.0 Universal license.

Indexed as

Databases, GeneticGene OntologySoftwareComputational BiologyHumansMolecular Sequence Annotation

Identifiers

PMID34986598
PMCPMC8728134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.