ArticleNeuroImage2022
Development and evaluation of a high resolution 0.5mm isotropic T1-weighted template of the older adult brain.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- Performance of CT-guided spatial normalization for semi-quantification of dopamine transporter SPECT and detection of nigrostriatal degeneration.Annals of nuclear medicine · 2026Article
- miniMORPH: A Morphometry Pipeline for Low-Field MRI in Infants.Human brain mapping · 2026Article
- Super-resolution ultrasound radiomics for pre-FNA prediction of nondiagnostic (Bethesda I) thyroid nodules.Frontiers in endocrinology · 2026Article
- Multi-Radiomics Features of Super-Resolution MRI for Predicting Minor Amputation in Wagner 3 Diabetic Foot Ulcers.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Comprehensive linkage between molecular biology and imaging radiomics for thyroid nodules.World journal of radiology · 2025Article
- The application of super-resolution ultrasound radiomics models in predicting the failure of conservative treatment for ectopic pregnancy.Reproductive biology and endocrinology : RB&E · 2025Article
- Super resolution using sparse sampling at portable ultra-low field MR.Frontiers in neurology · 2024Article
- High resolution 0.5mm isotropic TNeuroImage · 2023Article
- Deep-learning-based 3D super-resolution MRI radiomics model: superior predictive performance in preoperative T-staging of rectal cancer.European radiology · 2023Article
- Development of high quality TNeuroImage · 2022Article
- Simultaneous high-resolution TMagnetic resonance in medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Investigating the structure of the older adult brain at high spatial resolution is of high significance, and a dedicated older adult structural brain template with sub-millimeter resolution is currently lacking. Therefore, the purpose of this work was twofold: (A) to develop a 0.5mm isotropic resolution standardized T1-weighted template of the older adult brain by applying principles of super resolution to high quality MRI data from 222 older adults (65-95 years of age), and (B) to systematically compare the new template to other standardized and study-specific templates in terms of image quality and performance when used as a reference for alignment of older adult data. The new template exhibited higher spatial resolution and improved visualization of fine structural details of the older adult brain compared to a template constructed using a conventional template building approach and the same data. In addition, the new template exhibited higher image sharpness and did not contain image artifacts observed in some of the other templates considered in this work. Due to the above enhancements, the new template provided higher inter-subject spatial normalization precision for older adult data compared to the other templates, and consequently enabled detection of smaller inter-group morphometric differences in older adult data. Finally, the new template was among those that were most representative of older adult brain data. Overall, the new template constructed here is an important resource for studies of aging, and the findings of the present work have important implications in template selection for investigations on older adults.
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