Evidence map›Paper›PMID 34986335›Full record

ReviewCell metabolism2022

Metabolite discovery: Biochemistry's scientific driver.

Martin Giera, Oscar Yanes, Gary Siuzdak

Abstract readReview
In one paragraph

Review in Cell metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Leveraging 13C-Labeling to Assign Molecular Formulas to Unknown Yeast Metabolites.Journal of the American Society for Mass Spectrometry · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Nitric oxide tunes secreted metabolite bioactivity.bioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Martin GieraLeiden University Medical Center, Center for Proteomics and Metabolomics, Albinusdreef 2, Leiden 2333 ZA, the Netherlands.
Oscar YanesUniversitat Rovira i Virgili, Department of Electronic Engineering, IISPV, Tarragona, Spain; CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: oscar.yanes@urv.cat.
Gary SiuzdakScripps Center for Metabolomics, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: siuzdak@scripps.edu.

Funding

Therapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J., FOX, HOWARD S · 2000 to 2021
$37.7M
Metabolomics Technologies to Advance Biomedical ResearchR35GM130385 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI GARY E SIUZDAK · 2019 to 2026
$3.9M
Proteomic Strategies for AIDS and Drug Abuse - HIV and METH CNS SynergyP01DA026146 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CIBOROWSKI, PAWEL S · 2008 to 2010
$2.9M
Mummichog 3, aligning mass spectrometry data to biological networks - Neutral LossU01CA235493 · NCI · JACKSON LABORATORY · PI LI, SHUZHAO, SIUZDAK, GARY E · 2018 to 2021
$2.0M
NCI NIH HHS U01 CA235493NIDA NIH HHS P01 DA026146NIGMS NIH HHS R35 GM130385NIMH NIH HHS P30 MH062261
6 · The paper itself

Abstract

Metabolite identification represents a major challenge, and opportunity, for biochemistry. The collective characterization and quantification of metabolites in living organisms, with its many successes, represents a major biochemical knowledgebase and the foundation of metabolism's rebirth in the 21

Indexed as

Artificial IntelligenceMetabolomicsMagnetic Resonance SpectroscopyMass Spectrometryartificial intelligencebiochemistrymass spectrometrymetabolitesnuclear magnetic resonancestructureunknowns

Identifiers

PMID34986335
PMCPMC10131248

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.